Document Detail


Reduced amygdala serotonin transporter binding in posttraumatic stress disorder.
MedLine Citation:
PMID:  21855859     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The amygdala is a key site where alterations in the regulation of the serotonin transporter (5-HTT) may alter stress response. Deficient 5-HTT function and abnormal amygdala activity have been hypothesized to contribute to the pathophysiology of posttraumatic stress disorder (PTSD), but no study has evaluated the 5-HTT in humans with PTSD. On the basis of translational models, we hypothesized that patients diagnosed with PTSD would exhibit reduced amygdala 5-HTT expression as measured with positron emission tomography and the recently developed 5-HTT-selective radiotracer [(11)C]AFM.
METHODS: Fifteen participants with PTSD and 15 healthy control (HC) subjects without trauma history underwent a resting-state positron emission tomography scan.
RESULTS: [(11)C]AFM binding potential (BP(ND)) within the combined bilateral amygdala region of interest was significantly reduced in the PTSD group compared with the HC group (p = .027; 16.3% reduction), which was largely driven by the between-group difference in the left amygdala (p = .008; 20.5% reduction). Furthermore, amygdala [(11)C]AFM BP(ND) was inversely correlated with both Hamilton Rating Scale for Anxiety scores (r = -.55, p = .035) and Montgomery-Åsberg Depression Rating Scale scores (r = -.56, p = .029).
CONCLUSIONS: Our findings of abnormally reduced amygdala 5-HTT binding in PTSD and its association with higher anxiety and depression symptoms in PTSD patients support a translational neurobiological model of PTSD directly implicating dysregulated 5-HTT signaling within neural systems underlying threat detection and fear learning.
Authors:
James W Murrough; Yiyun Huang; Jian Hu; Shannan Henry; Wendol Williams; Jean-Dominique Gallezot; Christopher R Bailey; John H Krystal; Richard E Carson; Alexander Neumeister
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Biological psychiatry     Volume:  70     ISSN:  1873-2402     ISO Abbreviation:  Biol. Psychiatry     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-11-02     Completed Date:  2012-02-28     Revised Date:  2014-09-21    
Medline Journal Info:
Nlm Unique ID:  0213264     Medline TA:  Biol Psychiatry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1033-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Society of Biological Psychiatry. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Amygdala / drug effects,  metabolism*,  radionuclide imaging
Aniline Compounds / diagnostic use,  pharmacokinetics
Brain Mapping
Case-Control Studies
Female
Functional Laterality
Humans
Male
Middle Aged
Positron-Emission Tomography
Protein Binding
Serotonin Plasma Membrane Transport Proteins / metabolism*
Stress Disorders, Post-Traumatic / pathology*
Young Adult
Grant Support
ID/Acronym/Agency:
R01 MH096876/MH/NIMH NIH HHS; R21 MH085627/MH/NIMH NIH HHS; R21 MH085627/MH/NIMH NIH HHS; R21 MH085627-01/MH/NIMH NIH HHS; R21 MH085627-02/MH/NIMH NIH HHS; R21 MH096105/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/2-(2-(dimethylaminomethylphenylthio))-5-fluoromethylphenylamine; 0/Aniline Compounds; 0/Serotonin Plasma Membrane Transport Proteins
Comments/Corrections

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