| Reduced amygdala serotonin transporter binding in posttraumatic stress disorder. | |
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MedLine Citation:
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PMID: 21855859 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The amygdala is a key site where alterations in the regulation of the serotonin transporter (5-HTT) may alter stress response. Deficient 5-HTT function and abnormal amygdala activity have been hypothesized to contribute to the pathophysiology of posttraumatic stress disorder (PTSD), but no study has evaluated the 5-HTT in humans with PTSD. On the basis of translational models, we hypothesized that patients diagnosed with PTSD would exhibit reduced amygdala 5-HTT expression as measured with positron emission tomography and the recently developed 5-HTT-selective radiotracer [(11)C]AFM. METHODS: Fifteen participants with PTSD and 15 healthy control (HC) subjects without trauma history underwent a resting-state positron emission tomography scan. RESULTS: [(11)C]AFM binding potential (BP(ND)) within the combined bilateral amygdala region of interest was significantly reduced in the PTSD group compared with the HC group (p = .027; 16.3% reduction), which was largely driven by the between-group difference in the left amygdala (p = .008; 20.5% reduction). Furthermore, amygdala [(11)C]AFM BP(ND) was inversely correlated with both Hamilton Rating Scale for Anxiety scores (r = -.55, p = .035) and Montgomery-Åsberg Depression Rating Scale scores (r = -.56, p = .029). CONCLUSIONS: Our findings of abnormally reduced amygdala 5-HTT binding in PTSD and its association with higher anxiety and depression symptoms in PTSD patients support a translational neurobiological model of PTSD directly implicating dysregulated 5-HTT signaling within neural systems underlying threat detection and fear learning. |
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Authors:
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James W Murrough; Yiyun Huang; Jian Hu; Shannan Henry; Wendol Williams; Jean-Dominique Gallezot; Christopher R Bailey; John H Krystal; Richard E Carson; Alexander Neumeister |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Biological psychiatry Volume: 70 ISSN: 1873-2402 ISO Abbreviation: Biol. Psychiatry Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-11-02 Completed Date: 2012-02-28 Revised Date: 2013-06-05 |
Medline Journal Info:
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Nlm Unique ID: 0213264 Medline TA: Biol Psychiatry Country: United States |
Other Details:
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Languages: eng Pagination: 1033-8 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Society of Biological Psychiatry. All rights reserved. |
Affiliation:
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Mood and Anxiety Disorders Program, Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Amygdala / drug effects, metabolism*, radionuclide imaging Aniline Compounds / diagnostic use, pharmacokinetics Brain Mapping Case-Control Studies Female Functional Laterality Humans Male Middle Aged Positron-Emission Tomography Protein Binding Serotonin Plasma Membrane Transport Proteins / metabolism* Stress Disorders, Post-Traumatic / pathology* Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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R01 MH096876/MH/NIMH NIH HHS; R21 MH085627/MH/NIMH NIH HHS; R21 MH085627/MH/NIMH NIH HHS; R21 MH085627-01/MH/NIMH NIH HHS; R21 MH085627-02/MH/NIMH NIH HHS; R21 MH096105/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/2-(2-(dimethylaminomethylphenylthio))-5-fluoromethylphenylamine; 0/Aniline Compounds; 0/Serotonin Plasma Membrane Transport Proteins |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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