Document Detail

Reduced γ-aminobutyric acid in occipital and anterior cingulate cortices in primary insomnia: a link to major depressive disorder?
MedLine Citation:
PMID:  22318195     Owner:  NLM     Status:  MEDLINE    
Insomnia is closely related to major depressive disorder (MDD) both cross-sectionally and longitudinally, and as such, offers potential opportunities to refine our understanding of the neurobiology of both sleep and mood disorders. Clinical and basic science data suggest a role for reduced γ-aminobutyric acid (GABA) in both MDD and primary insomnia (PI). Here, we have utilized single-voxel proton magnetic spectroscopy (1H-MRS) at 4 Tesla to examine GABA relative to total creatine (GABA/Cr) in the occipital cortex (OC), anterior cingulate cortex (ACC), and thalamus in 20 non-medicated adults with PI (12 women) and 20 age- and sex-matched healthy sleeper comparison subjects. PI subjects had significantly lower GABA/Cr in the OC (p=0.0005) and ACC (p=0.03) compared with healthy sleepers. There was no significant difference in thalamic GABA/Cr between groups. After correction for multiple comparisons, GABA/Cr did not correlate significantly with insomnia severity measures among PI subjects. This study is the first to demonstrate regional reductions of GABA in PI in the OC and ACC. Reductions in GABA in similar brain regions in MDD using 1H-MRS suggest a common reduction in cortical GABA among PI and mood disorders.
David T Plante; J Eric Jensen; Laura Schoerning; John W Winkelman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-02-08
Journal Detail:
Title:  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology     Volume:  37     ISSN:  1740-634X     ISO Abbreviation:  Neuropsychopharmacology     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-04-13     Completed Date:  2012-08-14     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  8904907     Medline TA:  Neuropsychopharmacology     Country:  England    
Other Details:
Languages:  eng     Pagination:  1548-57     Citation Subset:  IM    
Department of Psychiatry, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
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MeSH Terms
Brain Mapping
Case-Control Studies
Creatine / metabolism
Depressive Disorder, Major / complications
Gyrus Cinguli / metabolism*,  radionuclide imaging
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Middle Aged
Occipital Lobe / metabolism*,  radionuclide imaging
Protons / diagnostic use
Retrospective Studies
Sleep Initiation and Maintenance Disorders / complications,  pathology*,  radionuclide imaging
Young Adult
gamma-Aminobutyric Acid / metabolism*
Reg. No./Substance:
0/Protons; 56-12-2/gamma-Aminobutyric Acid; 57-00-1/Creatine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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