| Reduced adult neurogenesis and altered emotional behaviors in autoimmune-prone B-cell activating factor transgenic mice. | |
| | |
MedLine Citation:
|
PMID: 20185032 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: It has been postulated that brain inflammatory processes associated with autoimmune diseases may be causative factors in emotional disorders. Accordingly, we examined emotional behaviors in autoimmune-prone cytokine B-cell-activating factor (BAFF) transgenic mice, a model of systemic lupus erythematosus, rheumatoid arthritis, and Sj?gren's syndrome. METHODS: Male BAFF transgenic mice were examined on a series of standard laboratory assays of emotionality. Mice were also tested for brain inflammation, stress-induced c-Fos expression, hippocampal progenitor cell proliferation, and hippocampal neurogenesis-dependent and neurogenesis-independent long-term potentiation (LTP). RESULTS: Our study revealed that older BAFF transgenic mice exhibit an anxiety-like phenotype associated with brain inflammation. Furthermore, anxious mice display an abnormal neuronal activation within the limbic system in response to mild anxiogenic stimuli. Proliferation of newly formed neurons in the subgranular zone of adult hippocampus was significantly decreased in anxious BAFF transgenic mice that also showed impaired neurogenesis-dependent and neurogenesis-independent dentate gyrus LTP. CONCLUSIONS: Our results suggest that anxiety associated with autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, and Sj?gren's syndrome can be linked to brain inflammation, impaired neurogenesis, and hippocampal plasticity. BAFF transgenic mice can be used in future studies to test compounds of therapeutic value for the treatment of mood disorders associated with autoimmune diseases. |
| | |
Authors:
|
Rosalia Crupi; Marco Cambiaghi; Linda Spatz; Ren? Hen; Mitchell Thorn; Eitan Friedman; Giuseppe Vita; Fortunato Battaglia |
Publication Detail:
|
Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Biological psychiatry Volume: 67 ISSN: 1873-2402 ISO Abbreviation: Biol. Psychiatry Publication Date: 2010 Mar |
Date Detail:
|
Created Date: 2010-02-26 Completed Date: 2010-05-18 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0213264 Medline TA: Biol Psychiatry Country: United States |
Other Details:
|
Languages: eng Pagination: 558-66 Citation Subset: IM |
Copyright Information:
|
Copyright 2010 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved. |
Affiliation:
|
Department of Physiology and Pharmacology, City University of New York Medical School, New York, New York, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Age Factors Animals Antigens, CD / metabolism Antigens, Differentiation, Myelomonocytic / metabolism Anxiety* / genetics, pathology, physiopathology B-Cell Activating Factor / genetics* Behavior, Animal / physiology Cell Proliferation Disease Models, Animal Electric Stimulation / methods Emotions / physiology* Encephalitis* / genetics, pathology, physiopathology Enzyme-Linked Immunosorbent Assay / methods Exploratory Behavior / physiology Gene Expression Regulation / genetics* Glial Fibrillary Acidic Protein / metabolism Hindlimb Suspension / methods Hippocampus / cytology Immunoglobulin G / blood Long-Term Potentiation / genetics Male Maze Learning / physiology Mice Mice, Inbred C57BL Mice, Transgenic Microtubule-Associated Proteins / metabolism Neurogenesis / genetics* Neurons / physiology Neuropeptides / metabolism Proto-Oncogene Proteins c-fos / metabolism Stem Cells / physiology Swimming / psychology |
| Chemical | |
Reg. No./Substance:
|
0/Antigens, CD; 0/Antigens, Differentiation, Myelomonocytic; 0/B-Cell Activating Factor; 0/CD68 antigen, human; 0/Glial Fibrillary Acidic Protein; 0/Immunoglobulin G; 0/Microtubule-Associated Proteins; 0/Neuropeptides; 0/Proto-Oncogene Proteins c-fos; 0/doublecortin protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: PQ Interval in Patients With Fabry Disease.
Next Document: The rotational model and microdialysis: Significance for dopamine signalling, clinical studies, and ...