| Reduced AMPK-ACC and mTOR signaling in muscle from older men, and effect of resistance exercise. | |
MedLine Citation:
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PMID: 23000302 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AMP-activated protein kinase (AMPK) is a key energy-sensitive enzyme that controls numerous metabolic and cellular processes. Mammalian target of rapamycin (mTOR) is another energy/nutrient-sensitive kinase that controls protein synthesis and cell growth. In this study we determined whether older versus younger men have alterations in the AMPK and mTOR pathways in skeletal muscle, and examined the effect of a long term resistance type exercise training program on these signaling intermediaries. Older men had decreased AMPKα2 activity and lower phosphorylation of AMPK and its downstream signaling substrate acetyl-CoA carboxylase (ACC). mTOR phosphylation also was reduced in muscle from older men. Exercise training increased AMPKα1 activity in older men, however, AMPKα2 activity, and the phosphorylation of AMPK, ACC and mTOR, were not affected. In conclusion, older men have alterations in the AMPK-ACC and mTOR pathways in muscle. In addition, prolonged resistance type exercise training induces an isoform-selective up regulation of AMPK activity. |
Authors:
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Mengyao Li; Lex B Verdijk; Kei Sakamoto; Brian Ely; Luc J C van Loon; Nicolas Musi |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2012-09-19 |
Journal Detail:
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Title: Mechanisms of ageing and development Volume: 133 ISSN: 1872-6216 ISO Abbreviation: Mech. Ageing Dev. Publication Date: 2012 Nov-Dec |
Date Detail:
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Created Date: 2012-12-11 Completed Date: 2013-05-23 Revised Date: 2013-11-06 |
Medline Journal Info:
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Nlm Unique ID: 0347227 Medline TA: Mech Ageing Dev Country: Ireland |
Other Details:
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Languages: eng Pagination: 655-64 Citation Subset: IM |
Copyright Information:
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Published by Elsevier Ireland Ltd. |
Affiliation:
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Geriatric Research, Education and Clinical Center, Audie L. Murphy Veterans Hospital, 7400 Merton Minter Blvd, San Antonio, TX 78229, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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AMP-Activated Protein Kinases
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metabolism Acetyl-CoA Carboxylase / metabolism* Adult Age Factors Aged Aged, 80 and over Biopsy Body Weight Exercise* Gene Expression Regulation, Enzymologic* Humans Male Middle Aged Muscles / metabolism* Phosphorylation Protein Kinases / metabolism* Resistance Training* Signal Transduction TOR Serine-Threonine Kinases / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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K23-AG030979/AG/NIA NIH HHS; R01 DK080157/DK/NIDDK NIH HHS; R01 DK089229/DK/NIDDK NIH HHS; R01-DK089229/DK/NIDDK NIH HHS; R01-DK80157/DK/NIDDK NIH HHS; //Medical Research Council |
| Chemical | |
Reg. No./Substance:
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EC 2.7.-/Protein Kinases; EC 2.7.1.-/AMP-activated protein kinase kinase; EC 2.7.1.1/MTOR protein, human; EC 2.7.1.1/TOR Serine-Threonine Kinases; EC 2.7.11.1/AMP-Activated Protein Kinases; EC 2.7.11.1/PRKAA1 protein, human; EC 2.7.11.1/PRKAA2 protein, human; EC 6.4.1.2/Acetyl-CoA Carboxylase |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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