Document Detail

Redox status in very-low birth-weight newborns.
MedLine Citation:
PMID:  14707434     Owner:  NLM     Status:  MEDLINE    
Inborn metabolic diseases, such as disorders in pyruvate metabolism, in gluconeogenesis or in the respiratory chain, may present with lactic acidosis in newborn infants. A simple tool to screen for the efficacy of mitochondrial oxidation reduction activity is the detection of the redox status through simultaneous measurements of plasma lactate, pyruvate and ketone bodies, which are strongly influenced by feeding and stress. We present the redox status values of 55 very-low birth-weight infants under different nutritional conditions. We were able to demonstrate that the redox status values are not dependent on the type of nutrition (oral feeding or continuous enteral nutrition). Instead we observed a strong difference between newborns with intrauterine growth retardation and newborns with appropriate growth. Newborns with intrauterine growth retardation show lower preprandial values of glucose and ketone bodies than newborns with appropriate weight, but higher levels of lactate and pyruvate; nevertheless the lactate/pyruvate and beta-hydroxybutyrate/acetoacetate ratios are normal. The results of the redox status study could suggest the reduced activity of gluconeogenesis and, probably, of beta-oxidation in very-low birth-weight newborns with intrauterine growth retardation.
L Filippi; A Messeri; C Dani; M Pezzati; M Tronchin; T Giani; S Bossoli; F F Rubaltelli
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Publication Detail:
Type:  Journal Article     Date:  2003-12-30
Journal Detail:
Title:  Biology of the neonate     Volume:  85     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  2004  
Date Detail:
Created Date:  2004-03-30     Completed Date:  2004-10-28     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  210-6     Citation Subset:  IM    
Copyright Information:
Copyright 2004 S. Karger AG, Basel
Neonatal Intensive Care Unit, Department of Critical Care Medicine, University Careggi Hospital, Florence, Italy.
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MeSH Terms
3-Hydroxybutyric Acid / blood
Acetoacetates / blood
Fetal Growth Retardation / metabolism*
Gluconeogenesis / physiology*
Glucose / metabolism
Infant Nutritional Physiological Phenomena
Infant, Newborn
Infant, Very Low Birth Weight / metabolism*
Ketone Bodies / blood
Lactic Acid / blood
Prospective Studies
Pyruvic Acid / blood
Reg. No./Substance:
0/Acetoacetates; 0/Ketone Bodies; 127-17-3/Pyruvic Acid; 300-85-6/3-Hydroxybutyric Acid; 50-21-5/Lactic Acid; 50-99-7/Glucose; 541-50-4/acetoacetic acid

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