Document Detail


Redox-responsive drug delivery.
MedLine Citation:
PMID:  24797814     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The objective of most modern drug delivery strategies is to maximize the effectiveness of drug molecules at diseased tissue and minimize their effects in healthy ones. This is most often achieved using (bio-) synthetic carrier systems that release the drug at the target location. One emerging strategy to achieve this is to destabilize carriers and release therapeutics using natural redox gradients in the body or associated with disease. The body, however, is composed of numerous micro-environments whose redox homeostasis, as well as its dysregulation due to disease, is complex. The original article and authoritative reviews that constitute this Forum discuss some of the particular redox features associated with disease, and presents an overview of how, chemically, redox-responsive drug delivery carriers can be designed to respond to these opportunities.
Authors:
Marc A Gauthier
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-5-5
Journal Detail:
Title:  Antioxidants & redox signaling     Volume:  -     ISSN:  1557-7716     ISO Abbreviation:  Antioxid. Redox Signal.     Publication Date:  2014 May 
Date Detail:
Created Date:  2014-5-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888899     Medline TA:  Antioxid Redox Signal     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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