Document Detail


Redox regulation of p53, redox effectors regulated by p53: a subtle balance.
MedLine Citation:
PMID:  22117613     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
SIGNIFICANCE: Reactive oxygen species (ROS), generated by cells as side products of biological reactions, function as secondary messengers by impacting a host of cellular networks involved in maintaining normal homeostatic growth as well as pathological disease states. Redox-sensitive proteins, such as the tumor suppressor protein p53, are susceptible to ROS-dependent modifications, which could impact their activities and/or biological functions.
RECENT ADVANCES: p53 is a transcription factor that controls a wide variety of target genes and regulates numerous cellular functions in response to stresses that lead to genomic instability. Thus, redox modifications of p53 could impact cell fate signaling and could have profound effects on pathways fundamental to maintaining cell and tissue integrity.
CRITICAL ISSUES: Recent studies present evidence that ROS function upstream of p53 in some model systems, while in others ROS production could be a downstream effect of p53 activation.
FUTURE DIRECTIONS: In this review, we describe how ROS production regulates p53 activity and how p53 can, in turn, influence cellular ROS production.
Authors:
Agnès Maillet; Shazib Pervaiz
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Publication Detail:
Type:  Journal Article; Review     Date:  2012-01-25
Journal Detail:
Title:  Antioxidants & redox signaling     Volume:  16     ISSN:  1557-7716     ISO Abbreviation:  Antioxid. Redox Signal.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-04-17     Completed Date:  2012-08-08     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  100888899     Medline TA:  Antioxid Redox Signal     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1285-94     Citation Subset:  IM    
Affiliation:
ROS, Apoptosis and Cancer Biology Laboratory, Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
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MeSH Terms
Descriptor/Qualifier:
Animals
Humans
Oxidation-Reduction
Tumor Suppressor Protein p53 / metabolism,  physiology*
Chemical
Reg. No./Substance:
0/Tumor Suppressor Protein p53

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