| Redox regulation of p53, redox effectors regulated by p53: a subtle balance. | |
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MedLine Citation:
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PMID: 22117613 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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SIGNIFICANCE: Reactive oxygen species (ROS), generated by cells as side products of biological reactions, function as secondary messengers by impacting a host of cellular networks involved in maintaining normal homeostatic growth as well as pathological disease states. Redox-sensitive proteins, such as the tumor suppressor protein p53, are susceptible to ROS-dependent modifications, which could impact their activities and/or biological functions. RECENT ADVANCES: p53 is a transcription factor that controls a wide variety of target genes and regulates numerous cellular functions in response to stresses that lead to genomic instability. Thus, redox modifications of p53 could impact cell fate signaling and could have profound effects on pathways fundamental to maintaining cell and tissue integrity. CRITICAL ISSUES: Recent studies present evidence that ROS function upstream of p53 in some model systems, while in others ROS production could be a downstream effect of p53 activation. FUTURE DIRECTIONS: In this review, we describe how ROS production regulates p53 activity and how p53 can, in turn, influence cellular ROS production. |
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Authors:
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Agnès Maillet; Shazib Pervaiz |
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Publication Detail:
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Type: Journal Article; Review Date: 2012-01-25 |
Journal Detail:
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Title: Antioxidants & redox signaling Volume: 16 ISSN: 1557-7716 ISO Abbreviation: Antioxid. Redox Signal. Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-04-17 Completed Date: 2012-08-08 Revised Date: 2012-09-10 |
Medline Journal Info:
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Nlm Unique ID: 100888899 Medline TA: Antioxid Redox Signal Country: United States |
Other Details:
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Languages: eng Pagination: 1285-94 Citation Subset: IM |
Affiliation:
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ROS, Apoptosis and Cancer Biology Laboratory, Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Humans Oxidation-Reduction Tumor Suppressor Protein p53 / metabolism, physiology* |
| Chemical | |
Reg. No./Substance:
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0/Tumor Suppressor Protein p53 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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