Document Detail

Redox regulation of cell survival.
MedLine Citation:
PMID:  18522489     Owner:  NLM     Status:  MEDLINE    
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) play important roles in regulation of cell survival. In general, moderate levels of ROS/RNS may function as signals to promote cell proliferation and survival, whereas severe increase of ROS/RNS can induce cell death. Under physiologic conditions, the balance between generation and elimination of ROS/RNS maintains the proper function of redox-sensitive signaling proteins. Normally, the redox homeostasis ensures that the cells respond properly to endogenous and exogenous stimuli. However, when the redox homeostasis is disturbed, oxidative stress may lead to aberrant cell death and contribute to disease development. This review focuses on the roles of key transcription factors, signal-transduction pathways, and cell-death regulators in affecting cell survival, and how the redox systems regulate the functions of these molecules. The current understanding of how disturbance in redox homeostasis may affect cell death and contribute to the development of diseases such as cancer and degenerative disorders is reviewed. We also discuss how the basic knowledge on redox regulation of cell survival can be used to develop strategies for the treatment or prevention of those diseases.
Dunyaporn Trachootham; Weiqin Lu; Marcia A Ogasawara; Rivera-Del Valle Nilsa; Peng Huang
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Antioxidants & redox signaling     Volume:  10     ISSN:  1557-7716     ISO Abbreviation:  Antioxid. Redox Signal.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-06-04     Completed Date:  2008-09-29     Revised Date:  2013-06-05    
Medline Journal Info:
Nlm Unique ID:  100888899     Medline TA:  Antioxid Redox Signal     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1343-74     Citation Subset:  IM    
Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
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MeSH Terms
Cell Survival / physiology
Homeostasis / physiology
Models, Biological
Reactive Nitrogen Species / metabolism*
Reactive Oxygen Species / metabolism*
Signal Transduction / physiology*
Grant Support
Reg. No./Substance:
0/Reactive Nitrogen Species; 0/Reactive Oxygen Species

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