Document Detail


Redox redux: protecting the ischemic myocardium.
MedLine Citation:
PMID:  22201673     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cardiac ischemia-reperfusion (I-R) injury occurs upon prompt restoration of blood flow to the ischemic myocardium after an acute myocardial infarction. Interestingly, many of the features of I-R injury are related to impaired mitochondrial signaling and mitochondrial dysfunction. Restoring cardiac energy bioavailability and reduction-oxidation (redox) signaling are therefore important in recovery after I-R injury. In this issue of the JCI, Yoshioka and colleagues describe an important and unexpected role for thioredoxin-interacting protein (TXNIP) in the control of mitochondrial respiration and cell energy metabolism. Their findings could open the door for development of TXNIP-targeted therapeutic approaches for the treatment of cardiac I-R injury.
Authors:
Oded N Spindel; Bradford C Berk
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Publication Detail:
Type:  Comment; Journal Article; Research Support, N.I.H., Extramural     Date:  2011-12-27
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  122     ISSN:  1558-8238     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-01-04     Completed Date:  2012-03-06     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  30-2     Citation Subset:  AIM; IM    
Affiliation:
Department of Medicine and Department of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, Aab Cardiovascular Research Institute, Rochester, New York 14642, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Carrier Proteins / antagonists & inhibitors*,  genetics*
Female
Humans
Male
Mitochondria, Heart / metabolism*
Myocardial Reperfusion Injury / metabolism*,  prevention & control*
Thioredoxins / antagonists & inhibitors*,  genetics*
Grant Support
ID/Acronym/Agency:
HL 106158/HL/NHLBI NIH HHS; R01 HL106158/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Carrier Proteins; 0/Txnip protein, mouse; 52500-60-4/Thioredoxins
Comments/Corrections
Comment On:
J Clin Invest. 2012 Jan 3;122(1):267-79   [PMID:  22201682 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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