| Redox redux: protecting the ischemic myocardium. | |
| | |
MedLine Citation:
|
PMID: 22201673 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Cardiac ischemia-reperfusion (I-R) injury occurs upon prompt restoration of blood flow to the ischemic myocardium after an acute myocardial infarction. Interestingly, many of the features of I-R injury are related to impaired mitochondrial signaling and mitochondrial dysfunction. Restoring cardiac energy bioavailability and reduction-oxidation (redox) signaling are therefore important in recovery after I-R injury. In this issue of the JCI, Yoshioka and colleagues describe an important and unexpected role for thioredoxin-interacting protein (TXNIP) in the control of mitochondrial respiration and cell energy metabolism. Their findings could open the door for development of TXNIP-targeted therapeutic approaches for the treatment of cardiac I-R injury. |
| | |
Authors:
|
Oded N Spindel; Bradford C Berk |
Related Documents
:
|
18986433 - Optimization of cardiac resynchronization therapy. 12204503 - Tissue doppler imaging predicts improved systolic performance and reversed left ventric... 22089813 - Early migration of an amplatzer muscular ventricular septal defect occluder device caus... |
Publication Detail:
|
Type: Comment; Journal Article; Research Support, N.I.H., Extramural Date: 2011-12-27 |
Journal Detail:
|
Title: The Journal of clinical investigation Volume: 122 ISSN: 1558-8238 ISO Abbreviation: J. Clin. Invest. Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-01-04 Completed Date: 2012-03-06 Revised Date: 2013-02-20 |
Medline Journal Info:
|
Nlm Unique ID: 7802877 Medline TA: J Clin Invest Country: United States |
Other Details:
|
Languages: eng Pagination: 30-2 Citation Subset: AIM; IM |
Affiliation:
|
Department of Medicine and Department of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, Aab Cardiovascular Research Institute, Rochester, New York 14642, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Carrier Proteins / antagonists & inhibitors*, genetics* Female Humans Male Mitochondria, Heart / metabolism* Myocardial Reperfusion Injury / metabolism*, prevention & control* Thioredoxins / antagonists & inhibitors*, genetics* |
| Grant Support | |
ID/Acronym/Agency:
|
HL 106158/HL/NHLBI NIH HHS; R01 HL106158/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Carrier Proteins; 0/Txnip protein, mouse; 52500-60-4/Thioredoxins |
| Comments/Corrections | |
Comment On:
|
J Clin Invest. 2012 Jan 3;122(1):267-79
[PMID:
22201682
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: TAp73alpha protects small cell lung carcinoma cells from caspase-2 induced mitochondrial mediated ap...
Next Document: IL-1 and atherosclerosis: a murine twist to an evolving human story.