| Redox considerations in female reproductive function and assisted reproduction: from molecular mechanisms to health implications. | |
| | |
MedLine Citation:
|
PMID: 18402550 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Physiological levels of reactive oxygen species (ROS) play an important regulatory role through various signaling transduction pathways in folliculogenesis, oocyte maturation, endometrial cycle, luteolysis, implantation, embryogenesis, and pregnancy. Persistent and elevated generation of ROS leads to a disturbance of redox potential that in turn causes oxidative stress (OS). Our literature review captures the role of ROS in modulating a range of physiological functions and pathological processes affecting the female reproductive life span and even thereafter (i.e., menopause). The role of OS in female reproduction is becoming increasingly important, as recent evidence suggest that it plays a part in conditions such as polycystic ovarian disease, endometriosis, spontaneous abortions, preeclampsia, hydatidiform mole, embryopathies, preterm labor, and intrauterine growth retardation. OS has been implicated in different reproductive scenarios and is detrimental to both natural and assisted fertility. Many extrinsic and intrinsic conditions exist in assisted reproduction settings that can be tailored to reduce the toxic effects of ROS. Laboratory personnel should avoid procedures that are known to be deleterious, especially when safer procedures that can prevent OS are available. Although antioxidants such as folate, zinc, and thiols may help enhance fertility, the available data are contentious and must be evaluated in controlled studies with larger populations. |
| | |
Authors:
|
Ashok Agarwal; Sajal Gupta; Lucky Sekhon; Rani Shah |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Antioxidants & redox signaling Volume: 10 ISSN: 1557-7716 ISO Abbreviation: Antioxid. Redox Signal. Publication Date: 2008 Aug |
Date Detail:
|
Created Date: 2008-06-04 Completed Date: 2008-09-29 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100888899 Medline TA: Antioxid Redox Signal Country: United States |
Other Details:
|
Languages: eng Pagination: 1375-403 Citation Subset: IM |
Affiliation:
|
Reproductive Research Center, Department of Obstetrics and Gynecology, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA. agarwaa@ccf.org |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Female Humans Male Models, Biological Oxidation-Reduction Oxidative Stress / physiology* Pregnancy Reactive Oxygen Species / metabolism Reproduction / physiology* |
| Chemical | |
Reg. No./Substance:
|
0/Reactive Oxygen Species |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Cattle density and Shiga toxin-producing Escherichia coli infection in Germany: increased risk for m...
Next Document: Gene-modified mesenchymal stem cells express functionally active nerve growth factor on an engineere...