Document Detail


Redox considerations in female reproductive function and assisted reproduction: from molecular mechanisms to health implications.
MedLine Citation:
PMID:  18402550     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Physiological levels of reactive oxygen species (ROS) play an important regulatory role through various signaling transduction pathways in folliculogenesis, oocyte maturation, endometrial cycle, luteolysis, implantation, embryogenesis, and pregnancy. Persistent and elevated generation of ROS leads to a disturbance of redox potential that in turn causes oxidative stress (OS). Our literature review captures the role of ROS in modulating a range of physiological functions and pathological processes affecting the female reproductive life span and even thereafter (i.e., menopause). The role of OS in female reproduction is becoming increasingly important, as recent evidence suggest that it plays a part in conditions such as polycystic ovarian disease, endometriosis, spontaneous abortions, preeclampsia, hydatidiform mole, embryopathies, preterm labor, and intrauterine growth retardation. OS has been implicated in different reproductive scenarios and is detrimental to both natural and assisted fertility. Many extrinsic and intrinsic conditions exist in assisted reproduction settings that can be tailored to reduce the toxic effects of ROS. Laboratory personnel should avoid procedures that are known to be deleterious, especially when safer procedures that can prevent OS are available. Although antioxidants such as folate, zinc, and thiols may help enhance fertility, the available data are contentious and must be evaluated in controlled studies with larger populations.
Authors:
Ashok Agarwal; Sajal Gupta; Lucky Sekhon; Rani Shah
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Antioxidants & redox signaling     Volume:  10     ISSN:  1557-7716     ISO Abbreviation:  Antioxid. Redox Signal.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-06-04     Completed Date:  2008-09-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888899     Medline TA:  Antioxid Redox Signal     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1375-403     Citation Subset:  IM    
Affiliation:
Reproductive Research Center, Department of Obstetrics and Gynecology, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA. agarwaa@ccf.org
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MeSH Terms
Descriptor/Qualifier:
Animals
Female
Humans
Male
Models, Biological
Oxidation-Reduction
Oxidative Stress / physiology*
Pregnancy
Reactive Oxygen Species / metabolism
Reproduction / physiology*
Chemical
Reg. No./Substance:
0/Reactive Oxygen Species

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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