| Redox biology and gastric carcinogenesis: the role of Helicobacter pylori. | |
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MedLine Citation:
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PMID: 21605492 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Almost half the world's population is infected by Helicobacter pylori (H. pylori). This bacterium increases the production of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in human stomach, and this has been reported to impact upon gastric inflammation and carcinogenesis. However, the precise mechanism by which H. pylori induces gastric carcinogenesis is presently unclear. Although the main source of ROS/RNS production is possibly the host neutrophil, H. pylori itself produces O(2)(•-). Furthermore, its cytotoxin induces ROS production by gastric epithelial cells, which might affect intracellular signal transduction, resulting in gastric carcinogenesis. Excessive ROS production in gastric epithelial cells can cause DNA damage and thus might be involved in gastric carcinogenesis. Understanding the molecular mechanism of H. pylori-induced carcinogenesis is important for developing new strategies against gastric cancer. |
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Authors:
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Osamu Handa; Yuji Naito; Toshikazu Yoshikawa |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Redox report : communications in free radical research Volume: 16 ISSN: 1743-2928 ISO Abbreviation: Redox Rep. Publication Date: 2011 |
Date Detail:
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Created Date: 2011-05-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9511366 Medline TA: Redox Rep Country: England |
Other Details:
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Languages: eng Pagination: 1-7 Citation Subset: IM |
Affiliation:
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Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan. |
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Descriptor/Qualifier:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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