| The redox status in rats treated with flaxseed oil and lead-induced hepatotoxicity. | |
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MedLine Citation:
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PMID: 20960072 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Lead is a persistent environmental pollutant, and its toxicity continues to be a major health problem due to its interference with natural environment. In the present study, we have evaluated the effect of flaxseed oil on lead acetate-mediated hepatic oxidative stress and toxicity in rats. Lead acetate enhanced lipid peroxidation and nitric oxide production in both serum and liver with concomitant reduction in glutathione, catalase, superoxide dismutase, glutathione reductase, glutathione-S-transferase, and glutathione peroxidase activities, these findings were associated with DNA fragmentation. In addition, lead acetate caused liver injury as indicated by histopathological changed of the liver with an elevation in total bilirubin, serum alanine aminotransferase, aspartate aminotransferase, γ-glutamyl transpeptidase, and alkaline phosphatase. Treatment of rats with flaxseed oil resulted in marked improvement in most of the studied parameters as well as histopathological features. On the basis of the above results it can hypothesized that flaxseed oil is a natural product can be protect against lead acetate-mediated hepatic cytotoxicity. |
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Authors:
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Ahmed E Abdel-Moneim; Mohamed A Dkhil; Saleh Al-Quraishy |
Publication Detail:
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Type: Journal Article Date: 2010-10-20 |
Journal Detail:
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Title: Biological trace element research Volume: 143 ISSN: 1559-0720 ISO Abbreviation: Biol Trace Elem Res Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-09-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7911509 Medline TA: Biol Trace Elem Res Country: United States |
Other Details:
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Languages: eng Pagination: 457-67 Citation Subset: IM |
Affiliation:
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Department of Zoology and Entomology, Faculty of Science, Helwan University, Cairo, Egypt, aest1977@hotmail.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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