Document Detail

Redox regulation of gamma-glutamyl transpeptidase.
MedLine Citation:
PMID:  19684307     Owner:  NLM     Status:  MEDLINE    
gamma-Glutamyl transpeptidase (GGT) catalyzes the transfer of the glutamyl moiety from glutathione, and glutathione S-conjugates to acceptors to form another amide or to water to produce free glutamate. Functionally, GGT plays important roles in glutathione homeostasis and mercapturic acid metabolism. The expression of GGT is increased as an adaptive response upon the exposure of oxidative stress. The underlying mechanism of this, however, is nebulous, as GGT gene structure is complex and its transcription is usually controlled by multiple promoters that generate several subtypes of GGT mRNAs. Studies reveal that signaling pathways such as Ras, ERK, p38MAPK, and PI3K are involved in the induction of GGT gene expression in response to oxidative stress. Thus, not surprisingly, induction of GGT mRNA subtypes and the involvement of multiple signaling pathways vary depending on cell type and stimuli.
Hongqiao Zhang; Henry Jay Forman
Related Documents :
10082827 - Transfection and overexpression of metallothionein-i in neonatal rat primary astrocyte ...
17355747 - Metallothionein expression in the high-risk carotid atherosclerotic plaque.
18424257 - (-)-epigallocatechin gallate induces nrf2-mediated antioxidant enzyme expression via ac...
12729917 - A metallothionein and cpx-atpase handle heavy-metal tolerance in the filamentous cyanob...
21175807 - Hepatocellular carcinoma with persistent hepatitis b virus infection shows unusual down...
19002177 - Expression of the inhibitor of dna-binding (id)-1 protein as an angiogenic mediator in ...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2009-08-14
Journal Detail:
Title:  American journal of respiratory cell and molecular biology     Volume:  41     ISSN:  1535-4989     ISO Abbreviation:  Am. J. Respir. Cell Mol. Biol.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-10-21     Completed Date:  2009-11-23     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  8917225     Medline TA:  Am J Respir Cell Mol Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  509-15     Citation Subset:  IM    
School of Natural Sciences, University of California, Merced, Merced, CA 95340, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Acetylcysteine / metabolism
Adaptation, Physiological
Binding Sites
Enzyme Induction
Glutathione / metabolism
Lung / enzymology*
Oxidative Stress* / genetics
Promoter Regions, Genetic
RNA, Messenger / biosynthesis
Signal Transduction* / genetics
Transcription Factors / metabolism
Transcription, Genetic
gamma-Glutamyltransferase / biosynthesis*,  genetics
Grant Support
Reg. No./Substance:
0/RNA, Messenger; 0/Transcription Factors; 616-91-1/Acetylcysteine; 70-18-8/Glutathione; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Functions of Membrane Binding Domain of CTP:Phosphocholine Cytidylyltransferase in Alveolar Type II ...
Next Document:  Stretch-induced mitogen-activated protein kinase activation in lung fibroblasts is independent of re...