| Redox regulation of gamma-glutamyl transpeptidase. | |
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MedLine Citation:
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PMID: 19684307 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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gamma-Glutamyl transpeptidase (GGT) catalyzes the transfer of the glutamyl moiety from glutathione, and glutathione S-conjugates to acceptors to form another amide or to water to produce free glutamate. Functionally, GGT plays important roles in glutathione homeostasis and mercapturic acid metabolism. The expression of GGT is increased as an adaptive response upon the exposure of oxidative stress. The underlying mechanism of this, however, is nebulous, as GGT gene structure is complex and its transcription is usually controlled by multiple promoters that generate several subtypes of GGT mRNAs. Studies reveal that signaling pathways such as Ras, ERK, p38MAPK, and PI3K are involved in the induction of GGT gene expression in response to oxidative stress. Thus, not surprisingly, induction of GGT mRNA subtypes and the involvement of multiple signaling pathways vary depending on cell type and stimuli. |
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Authors:
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Hongqiao Zhang; Henry Jay Forman |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2009-08-14 |
Journal Detail:
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Title: American journal of respiratory cell and molecular biology Volume: 41 ISSN: 1535-4989 ISO Abbreviation: Am. J. Respir. Cell Mol. Biol. Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-10-21 Completed Date: 2009-11-23 Revised Date: 2010-11-02 |
Medline Journal Info:
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Nlm Unique ID: 8917225 Medline TA: Am J Respir Cell Mol Biol Country: United States |
Other Details:
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Languages: eng Pagination: 509-15 Citation Subset: IM |
Affiliation:
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School of Natural Sciences, University of California, Merced, Merced, CA 95340, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcysteine
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metabolism Adaptation, Physiological Animals Binding Sites Enzyme Induction Glutathione / metabolism Humans Lung / enzymology* Mice Oxidation-Reduction Oxidative Stress* / genetics Promoter Regions, Genetic RNA, Messenger / biosynthesis Rats Signal Transduction* / genetics Transcription Factors / metabolism Transcription, Genetic gamma-Glutamyltransferase / biosynthesis*, genetics |
| Grant Support | |
ID/Acronym/Agency:
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ES05511/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/RNA, Messenger; 0/Transcription Factors; 616-91-1/Acetylcysteine; 70-18-8/Glutathione; EC 2.3.2.2/gamma-Glutamyltransferase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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