Document Detail


Redox regulation of gamma-glutamyl transpeptidase.
MedLine Citation:
PMID:  19684307     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
gamma-Glutamyl transpeptidase (GGT) catalyzes the transfer of the glutamyl moiety from glutathione, and glutathione S-conjugates to acceptors to form another amide or to water to produce free glutamate. Functionally, GGT plays important roles in glutathione homeostasis and mercapturic acid metabolism. The expression of GGT is increased as an adaptive response upon the exposure of oxidative stress. The underlying mechanism of this, however, is nebulous, as GGT gene structure is complex and its transcription is usually controlled by multiple promoters that generate several subtypes of GGT mRNAs. Studies reveal that signaling pathways such as Ras, ERK, p38MAPK, and PI3K are involved in the induction of GGT gene expression in response to oxidative stress. Thus, not surprisingly, induction of GGT mRNA subtypes and the involvement of multiple signaling pathways vary depending on cell type and stimuli.
Authors:
Hongqiao Zhang; Henry Jay Forman
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2009-08-14
Journal Detail:
Title:  American journal of respiratory cell and molecular biology     Volume:  41     ISSN:  1535-4989     ISO Abbreviation:  Am. J. Respir. Cell Mol. Biol.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-10-21     Completed Date:  2009-11-23     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  8917225     Medline TA:  Am J Respir Cell Mol Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  509-15     Citation Subset:  IM    
Affiliation:
School of Natural Sciences, University of California, Merced, Merced, CA 95340, USA.
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MeSH Terms
Descriptor/Qualifier:
Acetylcysteine / metabolism
Adaptation, Physiological
Animals
Binding Sites
Enzyme Induction
Glutathione / metabolism
Humans
Lung / enzymology*
Mice
Oxidation-Reduction
Oxidative Stress* / genetics
Promoter Regions, Genetic
RNA, Messenger / biosynthesis
Rats
Signal Transduction* / genetics
Transcription Factors / metabolism
Transcription, Genetic
gamma-Glutamyltransferase / biosynthesis*,  genetics
Grant Support
ID/Acronym/Agency:
ES05511/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/RNA, Messenger; 0/Transcription Factors; 616-91-1/Acetylcysteine; 70-18-8/Glutathione; EC 2.3.2.2/gamma-Glutamyltransferase
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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