| Redistribution of pulmonary blood flow impacts thermodilution-based extravascular lung water measurements in a model of acute lung injury. | |
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MedLine Citation:
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PMID: 19809280 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Studies using transthoracic thermodilution have demonstrated increased extravascular lung water (EVLW) measurements attributed to progression of edema and flooding during sepsis and acute lung injury. The authors hypothesized that redistribution of pulmonary blood flow can cause increased apparent EVLW secondary to increased perfusion of thermally silent tissue, not increased lung edema. METHODS: Anesthetized, mechanically ventilated canines were instrumented with PiCCO (Pulsion Medical, Munich, Germany) catheters and underwent lung injury by repetitive saline lavage. Hemodynamic and respiratory physiologic data were recorded. After stabilized lung injury, endotoxin was administered to inactivate hypoxic pulmonary vasoconstriction. Computed tomographic imaging was performed to quantify in vivo lung volume, total tissue (fluid) and air content, and regional distribution of blood flow. RESULTS: Lavage injury caused an increase in airway pressures and decreased arterial oxygen content with minimal hemodynamic effects. EVLW and shunt fraction increased after injury and then markedly after endotoxin administration. Computed tomographic measurements quantified an endotoxin-induced increase in pulmonary blood flow to poorly aerated regions with no change in total lung tissue volume. CONCLUSIONS: The abrupt increase in EVLW and shunt fraction after endotoxin administration is consistent with inactivation of hypoxic pulmonary vasoconstriction and increased perfusion to already flooded lung regions that were previously thermally silent. Computed tomographic studies further demonstrate in vivo alterations in regional blood flow (but not lung water) and account for these alterations in shunt fraction and EVLW. |
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Authors:
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R Blaine Easley; Daniel G Mulreany; Christopher T Lancaster; Jason W Custer; Ana Fernandez-Bustamante; Elizabeth Colantuoni; Brett A Simon |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Anesthesiology Volume: 111 ISSN: 1528-1175 ISO Abbreviation: Anesthesiology Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-10-28 Completed Date: 2009-11-13 Revised Date: 2010-12-03 |
Medline Journal Info:
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Nlm Unique ID: 1300217 Medline TA: Anesthesiology Country: United States |
Other Details:
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Languages: eng Pagination: 1065-74 Citation Subset: AIM; IM |
Affiliation:
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Department of Anesthesiology, Johns Hopkins Medical Institutes, Baltimore, Maryland 21287, USA. beasley@jhmi.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Lung Injury
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physiopathology* Animals Disease Models, Animal Dogs Extravascular Lung Water* Lipopolysaccharides / toxicity Lung / radiography Positive-Pressure Respiration Pulmonary Circulation* Thermodilution* Tomography, X-Ray Computed |
| Grant Support | |
ID/Acronym/Agency:
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HL073994/HL/NHLBI NIH HHS; HL64368/HL/NHLBI NIH HHS; P50 HL073994-01/HL/NHLBI NIH HHS; R01 HL064368-01/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Lipopolysaccharides |
| Comments/Corrections | |
Comment In:
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Anesthesiology. 2009 Nov;111(5):933-5
[PMID:
19858867
]
Anesthesiology. 2010 Jun;112(6):1540-1; author reply 1541-2 [PMID: 20502125 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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