Document Detail

Redistribution in combinatorial synthesis. A theoretical approach.
MedLine Citation:
PMID:  10903379     Owner:  NLM     Status:  MEDLINE    
In modified versions of the split-mix method, the conventional solid support resin was replaced by labeled macroscopic support units in order to produce individual compounds in multi milligram quantities while the high productivity of the original procedure is preserved. Recently it has also been shown that tagging the units is unnecessary. Omission of the tags is possible if (i) the unlabeled support units are arranged into spatially ordered groups and the relative spatial arrangement of the units is maintained during the chemical reactions (ii) the support units are redistributed between the reaction steps according to a predetermined pattern permitted by the combinatorial redistribution rule and (iii) the sorting process is simulated by a computer that can trace the synthetic history of each support unit. Different kinds of solid support units, formation of spatially ordered groups, sorting devices and basic redistribution patterns (serial, semi-parallel and parallel) are discussed. It is also shown that particularly the semi-parallel and the parallel redistribution assure fast sorting.
A Furka
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Combinatorial chemistry & high throughput screening     Volume:  3     ISSN:  1386-2073     ISO Abbreviation:  Comb. Chem. High Throughput Screen.     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-08-23     Completed Date:  2000-08-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9810948     Medline TA:  Comb Chem High Throughput Screen     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  197-209     Citation Subset:  IM    
E]otv]os Lor¿and University, Department of Organic Chemistry, Budapest, Hungary.
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MeSH Terms
Combinatorial Chemistry Techniques*
Models, Theoretical*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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