Document Detail

Redistribution of carotid artery blood flow by 5-HT: effects of the 5-HT2 receptor antagonists ketanserin and Wal 1307.
MedLine Citation:
PMID:  6548449     Owner:  NLM     Status:  MEDLINE    
The study concerned effects of ketanserin and a new 5-HT2 receptor antagonist, Wal 1307, on the responses to 5-hydroxytryptamine (5-HT) in the porcine common carotid vascular bed. More than 80% of the total carotid blood flow (208 +/- 18 ml; n = 12) bypassed the tissues via arteriovenous anastomoses. Intracarotid infusions of 5-HT (2 micrograms X kg-1 X min-1) reduced the total carotid blood flow by about 50% and arteriovenous anastomotic flow by 85% but extracerebral tissue (nutrient) blood flow more than tripled. The cerebral component did not change. Thus, 5-HT appears to constrict large conducting arteries and arteriovenous anastomoses but dilates arterioles. Ketanserin and Wal 1307 did not affect carotid blood flow distribution but completely blocked the amine-induced reduction of total carotid blood flow. The constriction of arteriovenous anastomoses was only slightly reduced but the 5-HT-induced arteriolar, vasodilation was enhanced. We conclude that vasoconstriction in the main trunk of the carotid artery and, to a smaller degree, in the arteriovenous anastomoses and arterioles, is mediated by mediated by 5-HT2 receptors. The major part of the constriction of arteriovenous anastomoses and arteriolar dilation elicited by 5-HT is, however, not mediated by 5-HT2 receptors. It is argued that these 'atypical' 5-HT receptors may be related to 5-HT1 binding sites.
P D Verdouw; H M Jennewein; J Heiligers; D J Duncker; P R Saxena
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of pharmacology     Volume:  102     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1984 Jul 
Date Detail:
Created Date:  1984-12-12     Completed Date:  1984-12-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  499-509     Citation Subset:  IM    
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MeSH Terms
Carotid Arteries / drug effects*
Dibenzoxazepines / pharmacology*
Hemodynamics / drug effects
Piperidines / pharmacology*
Receptors, Serotonin / drug effects
Regional Blood Flow / drug effects
Serotonin / pharmacology*
Serotonin Antagonists / pharmacology*
Reg. No./Substance:
0/Dibenzoxazepines; 0/Piperidines; 0/Receptors, Serotonin; 0/Serotonin Antagonists; 50-67-9/Serotonin; 74050-98-9/Ketanserin; 92588-10-8/WAL 1307

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