| Redefining the management of pediatric tonsillopharyngitis with cefprozil. | |
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MedLine Citation:
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PMID: 18174646 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Tonsillopharyngitis is very common in children, with Group A Streptococci being the most common bacterial etiology. Effective antibacterial treatment is imperative due to risk of rheumatic fever. Cephalosporins have been used successfully for the treatment of Group A beta-hemolytic Streptococcal (GABHS) tonsillopharyngitis. Cefprozil is a novel broad-spectrum oral cephalosporin. Cefprozil is rapidly absorbed from the gastrointestinal tract with high bioavailability. The excellent penetration of cefprozil into tonsillar and adenoidal tissue corresponds well with the clinical outcome. The drug provides excellent coverage against both gram-negative and -positive bacteria that may cause pharyngitis/tonsillitis. The beta-lactamase stability of cefprozil appears to exceed that of other oral cephalosporins for important gram negative pathogens. In clinical trials, cefprozil appears to be at least as effective as commonly used comparison agents such as cefaclor and cefixime. Additionally, cefprozil is better tolerated than the latter, especially with regard to gastrointestinal adverse effects. Thus cefprozil can be considered a safe and reliable drug for the treatment of Streptococcal tonsillopharyngitis in children. |
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Authors:
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Nameet Jerath; Ganesh Shetty |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Indian journal of pediatrics Volume: 74 ISSN: 0973-7693 ISO Abbreviation: Indian J Pediatr Publication Date: 2007 Dec |
Date Detail:
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Created Date: 2008-01-04 Completed Date: 2008-02-01 Revised Date: 2009-07-15 |
Medline Journal Info:
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Nlm Unique ID: 0417442 Medline TA: Indian J Pediatr Country: India |
Other Details:
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Languages: eng Pagination: 1105-8 Citation Subset: IM |
Affiliation:
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Pediatric Intensivist, Indraprastha Apollo Hospital, New Delhi, India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Anti-Bacterial Agents / administration & dosage* Cephalosporins / administration & dosage*, adverse effects Child Child, Preschool Dose-Response Relationship, Drug Drug Administration Schedule Female Humans Infant Male Pharyngitis / drug therapy*, microbiology Randomized Controlled Trials as Topic Sensitivity and Specificity Tonsillitis / drug therapy*, microbiology Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Cephalosporins; 92665-29-7/cefprozil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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