Document Detail


Red wine and equivalent oral pharmacological doses of resveratrol delay vascular aging but do not extend life span in rats.
MedLine Citation:
PMID:  22818625     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To investigate, in male Wistar rats, the effects of long-term moderate red wine (RW) consumption (equivalent to ∼0.15 mg% resveratrol RS), or RS in low (L, 0.15 mg%) or high (H, 400 mg%) doses in chow.
BACKGROUND: Both RW and RS exhibit cardioprotection. RS extends lifespan in obese rats. It is unclear whether RW consumption or low-dose RS delay vascular aging and prolong life span in the absence of overt risk factors.
METHODS: Endpoints were aerobic performance, exercise capacity, aging biomarkers (p53,p16,p21, telomere length and telomerase activity in aortic homogenates), vascular reactivity. Data were compared with controls (C) given regular chow.
RESULTS: Expressions of p53 decreased ∼50% ∼with RW and LRS (p < 0.05 vs. C), p16 by ∼29% with RW (p < 0.05 vs. C) and p21 was unaltered. RW and LRS increased telomere length >6.5-fold vs. C, and telomerase activity increased with LRS and HRS. All treatments increased aerobic capacity (C 32.5 ± 1.2, RW 38.7 ± 1.7, LRS 38.5 ± 1.6, HRS 38.3 ± 1.8 mlO(2) min(-1) kg(-1)), and RW or LRS also improved time of exercise tolerance vs. C (p < 0.05). Endothelium-dependent relaxation improved with all treatments vs. C. Life span, however, was unaltered with each treatment vs. C = 673 ± 30 days, p = NS.
CONCLUSIONS: RW and LRS can preserve vascular function indexes in normal rats, although not extending life span. These effects were translated into better aerobic performance and exercise capacity.
Authors:
Protásio L da Luz; Leonardo Tanaka; Patrícia Chakur Brum; Paulo Magno Martins Dourado; Desidério Favarato; José Eduardo Krieger; Francisco Rafael M Laurindo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-06-26
Journal Detail:
Title:  Atherosclerosis     Volume:  224     ISSN:  1879-1484     ISO Abbreviation:  Atherosclerosis     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-24     Completed Date:  2013-01-16     Revised Date:  2013-06-03    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  136-42     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
Affiliation:
Clinical Division, Heart Institute (Incor), School of Medicine, University of São Paulo, SP, Brazil. protasio.luz@incor.usp.br
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MeSH Terms
Descriptor/Qualifier:
Aging / drug effects*
Animals
Aorta / metabolism
Blood Vessels / physiology
Endothelium-Dependent Relaxing Factors / metabolism
Exercise Test
Longevity / drug effects*
Male
Rats
Rats, Wistar
Stilbenes / administration & dosage*
Telomere / metabolism
Tumor Suppressor Protein p53 / metabolism
Wine
Chemical
Reg. No./Substance:
0/Endothelium-Dependent Relaxing Factors; 0/Stilbenes; 0/Tumor Suppressor Protein p53; Q369O8926L/resveratrol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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