Document Detail


Red mold rice extract represses amyloid beta peptide-induced neurotoxicity via potent synergism of anti-inflammatory and antioxidative effect.
MedLine Citation:
PMID:  18438657     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Amyloid beta-peptide (Abeta), a risk of Alzheimer's disease (AD), causes cell death by inflammation and oxidative stress. Red mold rice (RMR) fermented by Monascus species is regarded as cholesterol-lowering functional food in virtue of the metabolite monacolin K identified as lovastatin. In addition, RMR is also demonstrated to express antioxidation because of multiple antioxidants. Therefore, this study focuses on the synergism of RMR against Abeta neurotoxicity and compares the effect between lovastatin and RMR including monacolin K and other functional metabolites. In this study, RE 568, an ethanol extract of RMR produced by strain Monascus purpureus NTU 568, is used to protect PC12 cell against Abeta40 neurotoxicity. All tests contain the treatments with lovastatin or RE 568 including equal monacolin K levels in order to compare the effect and investigate whether other metabolites of RE 568 provide potent assistance against Abeta40 neurotoxicity. In the results, monacolin K represses Abeta40 neurotoxicity via repressing small G-protein-mediated inflammation, and other metabolites of RE 568 also exhibit potent antioxidative ability against Abeta-induced oxidative stress. Importantly, stronger effects on repressing the Abeta40-induced cell death, inflammation, and oxidative stress are performed by RE 568 than that by the equal levels of lovastatin, which results from a potent synergism made up of monacolin K, antioxidants, and anti-inflammatory agents. The present study is the first report to demonstrate the potent synergistic protection of RMR against Abeta40 neurotoxicity, which would cause RMR to be developed as potential and novel functional food for the prophylaxis of AD pathogenesis.
Authors:
Chun-Lin Lee; Jyh-Jye Wang; Tzu-Ming Pan
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-04-26
Journal Detail:
Title:  Applied microbiology and biotechnology     Volume:  79     ISSN:  0175-7598     ISO Abbreviation:  Appl. Microbiol. Biotechnol.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-09     Completed Date:  2008-10-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8406612     Medline TA:  Appl Microbiol Biotechnol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  829-41     Citation Subset:  IM    
Affiliation:
R&D Division, Sunway Biotechnology Company Limited, Taipei, Taiwan.
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MeSH Terms
Descriptor/Qualifier:
Alzheimer Disease / drug therapy*,  prevention & control
Amyloid beta-Protein / toxicity*
Animals
Anti-Inflammatory Agents / pharmacology*
Anticholesteremic Agents / pharmacology
Antioxidants / pharmacology*
Cell Survival / drug effects
Drug Synergism*
Drugs, Chinese Herbal / pharmacology*
Humans
Inflammation / drug therapy
Lovastatin / pharmacology
Monascus / metabolism
Oryza sativa / metabolism*
Oxidative Stress / drug effects
PC12 Cells
Rats
Signal Transduction / drug effects
Chemical
Reg. No./Substance:
0/Amyloid beta-Protein; 0/Anti-Inflammatory Agents; 0/Anticholesteremic Agents; 0/Antioxidants; 0/Drugs, Chinese Herbal; 75330-75-5/Lovastatin

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