| Red mold rice extract represses amyloid beta peptide-induced neurotoxicity via potent synergism of anti-inflammatory and antioxidative effect. | |
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MedLine Citation:
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PMID: 18438657 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Amyloid beta-peptide (Abeta), a risk of Alzheimer's disease (AD), causes cell death by inflammation and oxidative stress. Red mold rice (RMR) fermented by Monascus species is regarded as cholesterol-lowering functional food in virtue of the metabolite monacolin K identified as lovastatin. In addition, RMR is also demonstrated to express antioxidation because of multiple antioxidants. Therefore, this study focuses on the synergism of RMR against Abeta neurotoxicity and compares the effect between lovastatin and RMR including monacolin K and other functional metabolites. In this study, RE 568, an ethanol extract of RMR produced by strain Monascus purpureus NTU 568, is used to protect PC12 cell against Abeta40 neurotoxicity. All tests contain the treatments with lovastatin or RE 568 including equal monacolin K levels in order to compare the effect and investigate whether other metabolites of RE 568 provide potent assistance against Abeta40 neurotoxicity. In the results, monacolin K represses Abeta40 neurotoxicity via repressing small G-protein-mediated inflammation, and other metabolites of RE 568 also exhibit potent antioxidative ability against Abeta-induced oxidative stress. Importantly, stronger effects on repressing the Abeta40-induced cell death, inflammation, and oxidative stress are performed by RE 568 than that by the equal levels of lovastatin, which results from a potent synergism made up of monacolin K, antioxidants, and anti-inflammatory agents. The present study is the first report to demonstrate the potent synergistic protection of RMR against Abeta40 neurotoxicity, which would cause RMR to be developed as potential and novel functional food for the prophylaxis of AD pathogenesis. |
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Authors:
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Chun-Lin Lee; Jyh-Jye Wang; Tzu-Ming Pan |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2008-04-26 |
Journal Detail:
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Title: Applied microbiology and biotechnology Volume: 79 ISSN: 0175-7598 ISO Abbreviation: Appl. Microbiol. Biotechnol. Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-06-09 Completed Date: 2008-10-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8406612 Medline TA: Appl Microbiol Biotechnol Country: Germany |
Other Details:
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Languages: eng Pagination: 829-41 Citation Subset: IM |
Affiliation:
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R&D Division, Sunway Biotechnology Company Limited, Taipei, Taiwan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alzheimer Disease
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drug therapy*,
prevention & control Amyloid beta-Protein / toxicity* Animals Anti-Inflammatory Agents / pharmacology* Anticholesteremic Agents / pharmacology Antioxidants / pharmacology* Cell Survival / drug effects Drug Synergism* Drugs, Chinese Herbal / pharmacology* Humans Inflammation / drug therapy Lovastatin / pharmacology Monascus / metabolism Oryza sativa / metabolism* Oxidative Stress / drug effects PC12 Cells Rats Signal Transduction / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Amyloid beta-Protein; 0/Anti-Inflammatory Agents; 0/Anticholesteremic Agents; 0/Antioxidants; 0/Drugs, Chinese Herbal; 75330-75-5/Lovastatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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