| Red light-activated phosphorothioate oligodeoxyribonucleotides. | |
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MedLine Citation:
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PMID: 18625558 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hairpin-structured phosphorothioate oligodeoxyribonucleotides containing a singlet oxygen-sensitive linker in the loop were prepared. These compounds do not bind complementary nucleic acids in the dark. Upon irradiation with red light in the presence of chlorine e6 the linker within these compounds is cleaved and a single-stranded oligodeoxyribonucleotide is produced. The latter compound is an efficient binder of complementary nucleic acids. This is the first example of 'caged' phosphorothioate oligodeoxyribonucleotides, whose nucleic acid binding ability is triggered by red light. |
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Authors:
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Alexandru Rotaru; János Kovács; Andriy Mokhir |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-06-28 |
Journal Detail:
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Title: Bioorganic & medicinal chemistry letters Volume: 18 ISSN: 1464-3405 ISO Abbreviation: Bioorg. Med. Chem. Lett. Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-07-29 Completed Date: 2008-08-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9107377 Medline TA: Bioorg Med Chem Lett Country: England |
Other Details:
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Languages: eng Pagination: 4336-8 Citation Subset: IM |
Affiliation:
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Inorganic Chemistry Institute, University of Heidelberg, In Neuenheimer Feld 270, 69120 Heidelberg, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Light* Molecular Structure Oligodeoxyribonucleotides / chemical synthesis*, chemistry* Phosphorothioate Oligonucleotides / chemical synthesis*, chemistry* Singlet Oxygen / chemistry |
| Chemical | |
Reg. No./Substance:
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0/Oligodeoxyribonucleotides; 0/Phosphorothioate Oligonucleotides; 17778-80-2/Singlet Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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