| Red ginseng for type 2 diabetes mellitus: A systematic review of randomized controlled trials. | |
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MedLine Citation:
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PMID: 22139546 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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OBJECTIVE: Red ginseng (RG, Panax ginseng C.A. Meyer) is one of the widely used herbs for treating type 2 diabetes mellitus (DM). However, no systematic review of the effectiveness of RG for type 2 DM is available. This systematic review aimed to evaluate the current evidence for the effectiveness of RG in patients with type 2 DM. METHODS: Electronic searches of 14 electronic databases were conducted without language restrictions. All randomized clinical trials (RCTs) with RG as a treatment for type 2 DM were considered for inclusion. Their methodological quality was assessed using the Cochrane criteria. RESULTS: Four RCTs met our inclusion criteria. Their methodological quality was variable. Three of the RCTs compared the effectiveness of RG with placebo. The meta-analysis of these data failed to favor RG over placebo for fasting plasma glucose (FPG) [n =76, weighted mean difference (WMD): -0.43 mmol/L; 95% confidence interval (CI): -1.16 to 0.30, =0.25] and fasting plasma insulin (FPI) (n =76, WMD: -8.43 pmol/L; 95% CI: -19.54 to 2.68, P =0.14) for 12 weeks of treatment. One RCT compared the effects of RG with no treatment. The results did not suggest favorable effects of RG on FPG, hemoglobin A(1c) (HbA(1c)) or 2-h blood glucose after a meal (PP2h). CONCLUSIONS: The evidence for the effectiveness of RG in controlling glucose in type 2 DM is not convincing. Few included studies with various treatment regimens prohibit definitive conclusions. More rigorous studies are needed to clarify the effects of RG on this condition. |
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Authors:
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Sina Kim; Byung-Cheul Shin; Myeong Soo Lee; Hyangsook Lee; Edzard Ernst |
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Publication Detail:
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Type: Journal Article Date: 2011-12-03 |
Journal Detail:
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Title: Chinese journal of integrative medicine Volume: 17 ISSN: 1672-0415 ISO Abbreviation: Chin J Integr Med Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-05 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101181180 Medline TA: Chin J Integr Med Country: China |
Other Details:
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Languages: eng Pagination: 937-44 Citation Subset: IM |
Affiliation:
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School of Korean Medicine, Pusan National University, Yangsan, 626-870, South Korea. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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