Document Detail


Red cell membrane fatty acids, cytosolic phospholipase-A2 and schizophrenia.
MedLine Citation:
PMID:  9689723     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Forty subjects with schizophrenia and 40 age- and sex-matched controls were recruited, and blood samples were obtained for analysis of red cell membrane fatty acid composition by capillary gas chromatography. A blood sample was also taken from the same population to test for allelic association between schizophrenia and a polymorphism close to the promoter site of the cytosolic phospholipase-A2 gene which is mapped to chromosome 1q25. The schizophrenic population was heterogeneous with regards age, symptoms severity and treatment. A significantly higher percentage concentration of dihomogamma-linolenic acid (DGLA) was found in the red cell membranes of schizophrenics compared to matched controls. All other fatty acids examined showed no difference from the normal population. No correlation was found between any demographic factor, treatment variable, diet, drug use, alcohol or tobacco consumption which could explain the biochemical findings. A negative correlation was found between the concentration of DGLA in red blood cell (RBC) membranes and severity of symptoms of schizophrenia. In particular, there was a significant correlation (r = -0.41, p = 0.009) between DGLA percentage concentrations and 'disorganised' symptoms. No association was found between schizophrenia and alleles of the polymorphism near the phospholipase-A2 gene or between fatty acid concentrations and the presence of any particular alleles. This study therefore finds support for membrane phospholipid abnormalities in patients with schizophrenia and particular symptom clusters, but does not replicate a previous report of an allelic association between a polymorphism close to the site of the cytosolic phospholipase-A2 gene and schizophrenia.
Authors:
A B Doris; K Wahle; A MacDonald; S Morris; I Coffey; W Muir; D Blackwood
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Schizophrenia research     Volume:  31     ISSN:  0920-9964     ISO Abbreviation:  Schizophr. Res.     Publication Date:  1998 May 
Date Detail:
Created Date:  1998-11-09     Completed Date:  1998-11-09     Revised Date:  2010-09-02    
Medline Journal Info:
Nlm Unique ID:  8804207     Medline TA:  Schizophr Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  185-96     Citation Subset:  IM    
Affiliation:
University Department of Psychiatry, Royal Edinburgh Hospital, UK.
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MeSH Terms
Descriptor/Qualifier:
Adult
Alleles
Case-Control Studies
Erythrocyte Membrane / chemistry*
Fatty Acids / biosynthesis,  blood*
Female
Genetic Markers
Humans
Male
Matched-Pair Analysis
Membrane Lipids / blood*
Middle Aged
Phospholipases A / genetics*
Phospholipases A2
Polymorphism, Genetic
Schizophrenia / classification,  metabolism*
Chemical
Reg. No./Substance:
0/Fatty Acids; 0/Genetic Markers; 0/Membrane Lipids; EC 3.1.1.-/Phospholipases A; EC 3.1.1.4/Phospholipases A2
Comments/Corrections
Comment In:
Schizophr Res. 2000 Jan 21;41(2):383-6   [PMID:  10708349 ]

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