| Red cell membrane fatty acids, cytosolic phospholipase-A2 and schizophrenia. | |
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MedLine Citation:
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PMID: 9689723 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Forty subjects with schizophrenia and 40 age- and sex-matched controls were recruited, and blood samples were obtained for analysis of red cell membrane fatty acid composition by capillary gas chromatography. A blood sample was also taken from the same population to test for allelic association between schizophrenia and a polymorphism close to the promoter site of the cytosolic phospholipase-A2 gene which is mapped to chromosome 1q25. The schizophrenic population was heterogeneous with regards age, symptoms severity and treatment. A significantly higher percentage concentration of dihomogamma-linolenic acid (DGLA) was found in the red cell membranes of schizophrenics compared to matched controls. All other fatty acids examined showed no difference from the normal population. No correlation was found between any demographic factor, treatment variable, diet, drug use, alcohol or tobacco consumption which could explain the biochemical findings. A negative correlation was found between the concentration of DGLA in red blood cell (RBC) membranes and severity of symptoms of schizophrenia. In particular, there was a significant correlation (r = -0.41, p = 0.009) between DGLA percentage concentrations and 'disorganised' symptoms. No association was found between schizophrenia and alleles of the polymorphism near the phospholipase-A2 gene or between fatty acid concentrations and the presence of any particular alleles. This study therefore finds support for membrane phospholipid abnormalities in patients with schizophrenia and particular symptom clusters, but does not replicate a previous report of an allelic association between a polymorphism close to the site of the cytosolic phospholipase-A2 gene and schizophrenia. |
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Authors:
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A B Doris; K Wahle; A MacDonald; S Morris; I Coffey; W Muir; D Blackwood |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Schizophrenia research Volume: 31 ISSN: 0920-9964 ISO Abbreviation: Schizophr. Res. Publication Date: 1998 May |
Date Detail:
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Created Date: 1998-11-09 Completed Date: 1998-11-09 Revised Date: 2010-09-02 |
Medline Journal Info:
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Nlm Unique ID: 8804207 Medline TA: Schizophr Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 185-96 Citation Subset: IM |
Affiliation:
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University Department of Psychiatry, Royal Edinburgh Hospital, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Alleles Case-Control Studies Erythrocyte Membrane / chemistry* Fatty Acids / biosynthesis, blood* Female Genetic Markers Humans Male Matched-Pair Analysis Membrane Lipids / blood* Middle Aged Phospholipases A / genetics* Phospholipases A2 Polymorphism, Genetic Schizophrenia / classification, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids; 0/Genetic Markers; 0/Membrane Lipids; EC 3.1.1.-/Phospholipases A; EC 3.1.1.4/Phospholipases A2 |
| Comments/Corrections | |
Comment In:
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Schizophr Res. 2000 Jan 21;41(2):383-6
[PMID:
10708349
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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