Document Detail

Red cell indices in classification and treatment of anemias: from M.M. Wintrobes's original 1934 classification to the third millennium.
MedLine Citation:
PMID:  23449069     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: Measurements of red cell volume, hemoglobin (Hb) concentration and Hb content continue to play a crucial role in the differential diagnosis of anemias 80 years after the publication of Wintrobe's seminal work. Modern hematology analyzers provide additional data on the heterogeneity of these parameters (distribution width) and quantify similar parameters of reticulocytes as well. Red cell and reticulocyte cellular indices are widely used in the diagnosis and monitoring of hematological diseases.
RECENT FINDINGS: Quantification of hypochromic cells is valuable in the differential diagnosis of thalassemia trait and iron deficiency, and in monitoring therapeutic response to erythropoietic stimulating agents, while hyperchromic cells are an essential diagnostic component for hereditary spherocytosis and may correlate with hemolytic parameters in sickle cell disease. Values for these parameters however depend on the technology used. Red cell clearance is associated with a reduction in both Hb content and cell volume: normal cells are likely to be removed by the time they reach a volume of 72 fl. Reticulocyte parameters such as Hb content (CHr or ret-He) or maturity index (RMI) have shown value in a variety of hematological conditions. New findings from genetic association studies have identified several potential novel genes affecting red cell indices, which are not mediated by changes in iron availability.
SUMMARY: Red cell indices continue to provide an essential support to the diagnosis and monitoring of hematological diseases.
Carlo Brugnara; Narla Mohandas
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in hematology     Volume:  20     ISSN:  1531-7048     ISO Abbreviation:  Curr. Opin. Hematol.     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-09     Completed Date:  2013-09-16     Revised Date:  2014-04-08    
Medline Journal Info:
Nlm Unique ID:  9430802     Medline TA:  Curr Opin Hematol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  222-30     Citation Subset:  IM    
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MeSH Terms
Diagnosis, Differential
Erythrocyte Indices / physiology*
Hematologic Diseases / diagnosis*,  therapy

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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