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Red cell distribution width and risk for venous thromboembolism: A population-based cohort study.
MedLine Citation:
PMID:  24393657     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
INTRODUCTION: Red cell distribution width (RDW) has been associated with venous thromboembolism (VTE), but whether RDW is a predictor of first event of VTE is unknown. We investigated the association between RDW and incidence of first event of VTE in a population-based cohort.
MATERIALS AND METHODS: RDW was measured in 27 042 subjects (aged 45-73years, 60.6% women), without previous history of VTE or cancer within 5years before follow-up, who participated in the Malmö Diet and Cancer study during 1991-1996. Incidence of VTE was identified from the patient register and the cause of death register during a mean follow-up of 13.8years and studied in relation to RDW.
RESULTS: During follow-up, 991 subjects (57.5% women) were affected by VTE (pulmonary embolism or deep venous thrombosis of the lower limbs). After adjustment for potential confounding factors the hazard ratios (HR) for VTE for the second, third and fourth RDW quartiles 1.15 (95% confidence interval 0.94-1.41), 1.41 (1.14-1.73), 1.74 (1.38-2.21), respectively, were compared with the bottom quartile of RDW. In the multivariate model subjects with the top 5% of RDW values compared with the bottom quartile had an even higher risk (HR=2.51, 1.78-2.54). In receiver operating characteristic (ROC) analysis, the male specific area under the ROC curve (AUC) for RDW was 0.57 (95% CI 0.54-0.59). The female specific AUC was 0.56 (95% CI 0.53-0.58).
CONCLUSIONS: RDW was found to be associated with long-term incidence of first event of VTE among middle-aged subjects.
Authors:
Bengt Zöller; Olle Melander; Peter Svensson; Gunnar Engström
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-12-15
Journal Detail:
Title:  Thrombosis research     Volume:  -     ISSN:  1879-2472     ISO Abbreviation:  Thromb. Res.     Publication Date:  2013 Dec 
Date Detail:
Created Date:  2014-1-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0326377     Medline TA:  Thromb Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 Elsevier Ltd. All rights reserved.
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