| Red cell distribution width: an inexpensive and powerful prognostic marker in heart failure. | |
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MedLine Citation:
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PMID: 19926599 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: Red cell distribution width (RDW) is prognostic in patients with heart failure (HF), but it has not been compared with N-terminal brain natriuretic peptide (NT-proBNP). We sought to make this comparison. METHODS AND RESULTS: Patients referred to a specialist HF clinic between 2001 and 2008 were assessed comprehensively including medical history, echocardiogram, and blood tests. Cox-regression was used to assess the multivariable relationship between RDW, NT-proBNP, and all-cause mortality. A total of 1087 patients were recruited; median (IQR) follow-up was 52 months (29-66); age 72 years (64-78); 74% male; 70% ischaemic heart disease; 20% diabetic; 85% NYHA >or= 2, and 63% with at least moderate LV impairment (EF < 35% equivalent). In a multivariable model, both RDW and NT-proBNP were independently prognostic (RDW: chi(2) = 21.8 vs. 49.1 both P < 0.001). In a model using quartiles of each variable, the relative risk for each was similar for the second and third quartiles compared with the first. A larger increase in risk for NT-proBNP is seen in the fourth quartile. CONCLUSION: Red cell distribution width is a readily available test in the HF-population with similar independent prognostic power to NT-proBNP across the first to third quartiles. Prognostic models in HF should include RDW and further investigation is necessary to determine the pathological mechanism of the relationship. |
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Authors:
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Yahya Al-Najjar; Kevin M Goode; Jufen Zhang; John G F Cleland; Andrew L Clark |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: European journal of heart failure Volume: 11 ISSN: 1879-0844 ISO Abbreviation: Eur. J. Heart Fail. Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-11-20 Completed Date: 2010-02-05 Revised Date: 2011-06-08 |
Medline Journal Info:
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Nlm Unique ID: 100887595 Medline TA: Eur J Heart Fail Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1155-62 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Division of Cardiovascular and Respiratory Studies, Postgraduate Medical Institute, Castle Hill Hospital, Kingston-upon-Hull, East Yorkshire, UK. ys.najjar@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Erythrocyte Volume* Female Heart Failure / blood*, mortality Humans Male Middle Aged Natriuretic Peptide, Brain / blood Peptide Fragments / blood Prognosis Survival Rate |
| Chemical | |
Reg. No./Substance:
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0/Peptide Fragments; 0/pro-brain natriuretic peptide (1-76); 114471-18-0/Natriuretic Peptide, Brain |
| Comments/Corrections | |
Comment In:
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Eur J Heart Fail. 2010 Apr;12(4):415
[PMID:
20167580
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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