Document Detail

Red cell distribution width: an inexpensive and powerful prognostic marker in heart failure.
MedLine Citation:
PMID:  19926599     Owner:  NLM     Status:  MEDLINE    
AIMS: Red cell distribution width (RDW) is prognostic in patients with heart failure (HF), but it has not been compared with N-terminal brain natriuretic peptide (NT-proBNP). We sought to make this comparison.
METHODS AND RESULTS: Patients referred to a specialist HF clinic between 2001 and 2008 were assessed comprehensively including medical history, echocardiogram, and blood tests. Cox-regression was used to assess the multivariable relationship between RDW, NT-proBNP, and all-cause mortality. A total of 1087 patients were recruited; median (IQR) follow-up was 52 months (29-66); age 72 years (64-78); 74% male; 70% ischaemic heart disease; 20% diabetic; 85% NYHA >or= 2, and 63% with at least moderate LV impairment (EF < 35% equivalent). In a multivariable model, both RDW and NT-proBNP were independently prognostic (RDW: chi(2) = 21.8 vs. 49.1 both P < 0.001). In a model using quartiles of each variable, the relative risk for each was similar for the second and third quartiles compared with the first. A larger increase in risk for NT-proBNP is seen in the fourth quartile.
CONCLUSION: Red cell distribution width is a readily available test in the HF-population with similar independent prognostic power to NT-proBNP across the first to third quartiles. Prognostic models in HF should include RDW and further investigation is necessary to determine the pathological mechanism of the relationship.
Yahya Al-Najjar; Kevin M Goode; Jufen Zhang; John G F Cleland; Andrew L Clark
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  European journal of heart failure     Volume:  11     ISSN:  1879-0844     ISO Abbreviation:  Eur. J. Heart Fail.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-20     Completed Date:  2010-02-05     Revised Date:  2011-06-08    
Medline Journal Info:
Nlm Unique ID:  100887595     Medline TA:  Eur J Heart Fail     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1155-62     Citation Subset:  IM    
Department of Cardiology, Division of Cardiovascular and Respiratory Studies, Postgraduate Medical Institute, Castle Hill Hospital, Kingston-upon-Hull, East Yorkshire, UK.
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MeSH Terms
Erythrocyte Volume*
Heart Failure / blood*,  mortality
Middle Aged
Natriuretic Peptide, Brain / blood
Peptide Fragments / blood
Survival Rate
Reg. No./Substance:
0/Peptide Fragments; 0/pro-brain natriuretic peptide (1-76); 114471-18-0/Natriuretic Peptide, Brain
Comment In:
Eur J Heart Fail. 2010 Apr;12(4):415   [PMID:  20167580 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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