Document Detail


Red cell distribution width as a predictor of mortality in organophosphate insecticide poisoning.
MedLine Citation:
PMID:  24768665     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Suicide by organophosphate insecticide (OPI) poisoning is a major clinical concern (predominantly in developing countries), and 200000 deaths occur annually worldwide. Red cell distribution width (RDW) has been used to predict outcome in several clinical conditions. Here, we aimed to investigate the relationship between the RDW and 30-day mortality during OPI poisoning.
METHODS: This retrospective analysis was performed between January 2008 and July 2013 in patients admitted to the emergency department after OPI poisoning. A Kaplan-Meier 30-day survival curve was analyzed in patients stratified according to the optimal cut-off point of RDW defined using a receiver operating characteristic (ROC) curve. Multivariate Cox proportional hazards analyses were conducted to determine the independent prognostic factors for 30-day mortality.
RESULTS: Among 102 patients, 21 died, yielding a mortality of 20.6%. Elevated RDW was significantly associated with early mortality in patients with OPI poisoning. Levels of RDW that exceeded 13.5% (hazard ratio, 2.64; 95% confidence interval [CI], 1.05-6.60) were associated with increased mortality in the multivariate analysis. The area under the ROC curve of RDW was 0.675 (95% CI, 0.522-0.829).
CONCLUSIONS: This study showed that RDW is an independent predictor of 30-day mortality in patients with OPI poisoning.
Authors:
Changwoo Kang; In Sung Park; Dong Hoon Kim; Seong Chun Kim; Jin Hee Jeong; Soo Hoon Lee; Sang Bong Lee; Sang Min Jung; Tae-Sin Kang; Kyung-Woo Lee
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Publication Detail:
Type:  Journal Article     Date:  2014-03-06
Journal Detail:
Title:  The American journal of emergency medicine     Volume:  32     ISSN:  1532-8171     ISO Abbreviation:  Am J Emerg Med     Publication Date:  2014 Jul 
Date Detail:
Created Date:  2014-06-23     Completed Date:  2014-08-26     Revised Date:  2014-10-21    
Medline Journal Info:
Nlm Unique ID:  8309942     Medline TA:  Am J Emerg Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  743-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2014 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Cohort Studies
Erythrocyte Indices*
Female
Humans
Insecticides / poisoning*
Kaplan-Meier Estimate
Male
Middle Aged
Multivariate Analysis
Organophosphate Poisoning / blood*,  mortality
Prognosis
Proportional Hazards Models
ROC Curve
Retrospective Studies
Chemical
Reg. No./Substance:
0/Insecticides
Comments/Corrections
Comment In:
Am J Emerg Med. 2014 Aug;32(8):937   [PMID:  24894798 ]
Am J Emerg Med. 2014 Sep;32(9):1132   [PMID:  24985946 ]
Am J Emerg Med. 2014 Sep;32(9):1132-4   [PMID:  24974370 ]

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