Document Detail

Red cell aplasia in myelofibrosis with myeloid metaplasia. A distinct functional and clinical entity.
MedLine Citation:
PMID:  6192899     Owner:  NLM     Status:  MEDLINE    
Three patients with myelofibrosis with myeloid metaplasia are described. All three presented with grave anemia and red cell aplasia. Erythroid failure was the functional characteristic of erythropoiesis as resulted from erythrokinetic studies. Bone marrow was hypercellular or normocellular with hyperplasia of granuloblasts and megakaryocytes. Despite absent or mild splenomegaly at diagnosis, massive splenomegaly associated with a leukoerythroblastic blood film developed during the course of the disease. A relative young age (42-47 years), a subacute course of the disease and terminal blast crisis in two of them were the prominent clinical features of the patients. The differentiation from acute or malignant myelofibrosis is discussed. The patients appear to be a distinct subset within myelofibrosis with myeloid metaplasia.
G Barosi; A Baraldi; M Cazzola; P Spriano; U Magrini
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Cancer     Volume:  52     ISSN:  0008-543X     ISO Abbreviation:  Cancer     Publication Date:  1983 Oct 
Date Detail:
Created Date:  1983-10-21     Completed Date:  1983-10-21     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0374236     Medline TA:  Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1290-6     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Transfusion
Bone Marrow / pathology
Erythrocytes / cytology*
Follow-Up Studies
Middle Aged
Primary Myelofibrosis / complications,  pathology*,  therapy
Staining and Labeling

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