Document Detail

Red cell aggregability increases with the severity of venous insufficiency.
MedLine Citation:
PMID:  7658108     Owner:  NLM     Status:  MEDLINE    
Several studies have suggested the presence of hemorheological abnormalities in venous insufficiency. The present prospective study was carried out to determine whether the increase in hemorheological disturbances parallels the evolution of the disease. Patients were recruited among ambulant outpatients and classified in 3 evolution stages of venous insufficiency according to the clinical and functional examination. Once a certain number of patients were included, the following successive inclusions were made in order to match for age and sex, in the other stages of venous insufficiency, the previously included patients. Since blood rheology is frequently altered in hypertension, diabetes and several other vascular pathologies, patients with those pathologies were not included. Sixty nine patients with venous insufficiency and 23 healthy subjects were tested, making up twenty three matching sets. Red blood cell (RBC) aggregation and disaggregation were assessed with the SEFAM erythroaggregameter on blood samples adjusted to 40% hematocrit. Statistical analysis showed a significant difference for the aggregation index (p = 0.0001), disaggregation shear rate (p = 0.0001) and fibrinogen (p = 0.006) between the 4 groups. Aggregability parameters increased gradually with the evolution of the disease, while the fibrinogen rise was significant only when varicose veins were present (stages 2 and 3). This progressive rise in RBC aggregability with the aggravation of venous insufficiency, by superimposing to the haemodynamic deficit, is likely to induce the formation of RBC aggregates in vivo, to perpetuate venous stasis and to contribute to the development of severe skin damages.
A Chabanel; F Zuccarelli; M M Samama
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  International angiology : a journal of the International Union of Angiology     Volume:  14     ISSN:  0392-9590     ISO Abbreviation:  Int Angiol     Publication Date:  1995 Mar 
Date Detail:
Created Date:  1995-10-05     Completed Date:  1995-10-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8402693     Medline TA:  Int Angiol     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  69-73     Citation Subset:  IM    
Laboratoire Central d'Hématologie, Hôpital Hôtel-Dieu, Paris, France.
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MeSH Terms
Blood Viscosity
Case-Control Studies
Erythrocyte Aggregation*
Fibrinogen / analysis
Middle Aged
Prospective Studies
Severity of Illness Index
Venous Insufficiency / blood*
Reg. No./Substance:

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