Document Detail


Red blood cell transfusion, feeding and necrotizing enterocolitis in preterm infants.
MedLine Citation:
PMID:  21252964     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objective:Preliminary studies suggested an association between red blood cell (RBC) transfusion and necrotizing enterocolitis (NEC) in premature neonates. An advantageous effect of withholding feeds during transfusion has never been studied. We aimed, first, to determine whether preterm infants who developed NEC were more likely to be transfused in the 48 to 72 h before the diagnosis of NEC; second, to test if a strict policy of withholding feeds during transfusion would decrease the incidence of transfusion-associated NEC.Study Design:The study was conducted in two phases. Phase 1: a retrospective case-control study of premature low-birth weight (<32 weeks and <2500 g) infants who developed NEC over a 6-year period. Phase 2: a comparison study of the incidence of NEC during the 18-months preceding, and the 18 months following the change of practice to withholding feeds during RBC transfusion.Result:In the case-control study (25 infants with NEC and 25 controls), more infants in the NEC group received transfusions in the 48 and 72 h preceding diagnosis (56 vs 20% within 48 h, P=0.019; and 64 vs 24% within 72 h, P=0.01). The total number of transfusions and age of RBCs were not different between the two groups. Implementing the policy of withholding feeds during transfusion was associated with a decrease in the incidence of NEC from 5.3 to 1.3% (P=0.047).Conclusion:Infants who developed NEC frequently received RBC transfusions in the 48 and 72 h preceding presentation of NEC. A strict policy of withholding feeds during transfusion may have a protective effect from NEC.Journal of Perinatology advance online publication, 20 January 2011; doi:10.1038/jp.2010.157.
Authors:
M El-Dib; S Narang; E Lee; A N Massaro; H Aly
Related Documents :
12237934 - Paleodemographic comparison of a catastrophic and an attritional death assemblage.
12193834 - Hypochondriasis and fear of death.
23639744 - Histological chorioamnionitis: effects on premature delivery and neonatal prognosis.
23016614 - Oxygen administration for the resuscitation of term and preterm infants.
9477534 - Parasites of stomach and small intestine of 70 horses slaughtered in the netherlands.
11505164 - Congenital heart defects, maternal febrile illness, and multivitamin use: a population-...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-1-20
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  -     ISSN:  1476-5543     ISO Abbreviation:  -     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-1-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Departments of Pediatrics and Neonatology, The George Washington University, Children's National Medical Center, Washington, DC, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  'Haptoglobin concentrations in preterm and term newborns'.
Next Document:  Gastrointestinal complications associated with ibuprofen therapy for patent ductus arteriosus.