| Red blood cell transfusion-dependency implies a poor survival in primary myelofibrosis irrespective of IPSS and DIPSS. | |
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MedLine Citation:
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PMID: 20884708 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Risk stratification in primary myelofibrosis is currently based on two international prognostic scoring systems, neither of which takes into consideration red blood cell transfusion-dependency. In 288 consecutive patients with primary myelofibrosis, red blood cell transfusion-dependency at diagnosis affects survival independently of the International Prognostic Scoring System (P < 0.001). To evaluate the dynamic impact on survival of red blood cell transfusion-dependency, we performed a Cox's regression analysis with transfusion status as time-dependent covariate in 220 regularly followed patients with primary myelofibrosis. Patients who begin red blood cell transfusions anytime (n = 80, 36%) have a significantly worse survival compared to those who continue follow up without transfusions (HR: 7.8, 95%CI: 5.1-11.9; P < 0.001). Adjusting for Dynamic International Prognostic Scoring System in a multivariate analysis, red blood cell transfusion-dependency retained an independent prognostic impact on survival. This study suggests that red blood cell transfusion-dependency should be considered to improve risk stratification of primary myelofibrosis during follow up. |
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Authors:
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Chiara Elena; Francesco Passamonti; Elisa Rumi; Luca Malcovati; Luca Arcaini; Emanuela Boveri; Michele Merli; Daniela Pietra; Cristiana Pascutto; Mario Lazzarino |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-09-30 |
Journal Detail:
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Title: Haematologica Volume: 96 ISSN: 1592-8721 ISO Abbreviation: Haematologica Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-01-03 Completed Date: 2011-05-26 Revised Date: 2011-07-20 |
Medline Journal Info:
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Nlm Unique ID: 0417435 Medline TA: Haematologica Country: Italy |
Other Details:
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Languages: eng Pagination: 167-70 Citation Subset: IM |
Affiliation:
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Department of Hematology Oncology, Division of Hematology, University of Pavia Medical School and Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Cohort Studies Erythrocyte Transfusion / mortality* Female Follow-Up Studies Humans Male Middle Aged Patient Selection Primary Myelofibrosis / diagnosis, mortality*, therapy* Prognosis Retrospective Studies Risk Factors Survival Rate |
| Comments/Corrections | |
Comment In:
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Haematologica. 2011 Jan;96(1):8-10
[PMID:
21193428
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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