Document Detail

Red blood cell substitutes and artificial blood.
MedLine Citation:
PMID:  6832769     Owner:  NLM     Status:  MEDLINE    
Artificial substitutes for specific functional portions of blood are being developed. Perfluorocarbons have received the most publicity in recent years, and one, Fluosol-DA, is undergoing clinical trials in the United States. The perfluorocarbon emulsions physically dissolve oxygen, which distinguishes them from the chemical binding that occurs in hemoglobin. Fluosol-DA has been shown to transport oxygen in amounts that are probably clinically useful if the patient inspires an atmosphere with increased oxygen. A large clinical trial from Japan suggests that Fluosol-DA is safe to transfuse, although recent work suggests that Fluosol-DA may produce significant pulmonary reactions that can be prevented by steroid administration. These reactions are probably caused by complement activation by an emulsifying agent in Fluosol-DA. Recent applications of Fluosol-DA include use in a resuscitative fluid, use in occlusive vascular disease, an special applications, such as treatment of carbon monoxide poisoning, which take advantage of the solubility properties of perfluorocarbons.
R J Bowman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Human pathology     Volume:  14     ISSN:  0046-8177     ISO Abbreviation:  Hum. Pathol.     Publication Date:  1983 Mar 
Date Detail:
Created Date:  1983-05-05     Completed Date:  1983-05-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9421547     Medline TA:  Hum Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  218-20     Citation Subset:  IM    
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MeSH Terms
Anemia, Sickle Cell / therapy
Blood Substitutes*
Drug Combinations / physiology,  toxicity
Fluorocarbons / physiology,  toxicity
Hemorrhage / therapy
Reg. No./Substance:
0/Blood Substitutes; 0/Drug Combinations; 0/Fluorocarbons; 75216-20-5/Fluosol-DA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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