Document Detail


Red blood cell potassium and blood pressure in adolescents: a mixture analysis.
MedLine Citation:
PMID:  12325467     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND AIM: Evidence from epidemiological and clinical studies has implicated potassium (K+) depletion in the pathogenesis and maintenance of essential hypertension. In adolescents prone to develop hypertension in the future, several studies have shown an inverse relationship between K+ intake and blood pressure (BP). The aim of this study was to determine whether the variation of red blood cell K+ content (RBCKi) in adolescents could be explained by a single distribution or by a mixture of two or more distributions. If more than one distribution could be identified, we studied whether they differed in BP, parental hypertension and other variables. METHOD AND RESULTS: Adolescents (n = 100) were recruited from a High School in the city of Valencia, Venezuela. BP, anthropometric measurements and parental history of hypertension were obtained from each subject. Venous blood and urine sample were obtained for RBC, plasma urine electrolyte measurements. Mixture analysis was used to analyze RBCKi distribution. The distribution of RBCKi levels fit significantly better in a bimodal (p < 0.01) than a unimodal or trimodal distribution. Diastolic blood pressure (75 +/- 1 vs 72 +/- 2 mmHg), systolic blood pressure (SBP) (119 +/- 1 vs 113 +/- 2 mmHg) and pulse pressure (PP) (44 +/- 1 vs 41 +/- 2 mmHg) were higher in the subgroup with low-RBCKi, but only SBP and PP values were statistically significant (p < 0.05). The low-RBCKi subgroup had 40% of the hypertensive parents vs 20% in the high-RBCKi subgroup. Adolescents with low RBCKi were three times more likely to have a hypertensive parent than adolescents with high RBCKi (chi 2 = 3, p = 0.04). CONCLUSION: K+ depletion in RBC, its bimodal distribution and its strong association with BP and parental hypertension suggest that low RBCKi in adolescents might represent an early sign of K+ depletion that could contribute to the development of future hypertension.
Authors:
M C Delgado; A Delgado-Almeida
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nutrition, metabolism, and cardiovascular diseases : NMCD     Volume:  12     ISSN:  0939-4753     ISO Abbreviation:  Nutr Metab Cardiovasc Dis     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-09-27     Completed Date:  2003-01-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9111474     Medline TA:  Nutr Metab Cardiovasc Dis     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  112-6     Citation Subset:  IM    
Affiliation:
Division of Hypertension, 3918 Taubman Center, Box 0356, University of Michigan, Ann Arbor, MI 48109, USA. delgadoc@umich.edu
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Analysis of Variance
Biological Markers / analysis
Blood Pressure Determination
Erythrocytes / chemistry*
Female
Humans
Hypertension / diagnosis*,  epidemiology
Male
Mass Screening
Potassium / analysis,  blood*
Probability
Sampling Studies
Sensitivity and Specificity
Venezuela / epidemiology
Chemical
Reg. No./Substance:
0/Biological Markers; 7440-09-7/Potassium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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