Document Detail

Red blood cell deformability and aggregation, cell adhesion molecules, oxidative stress and nitric oxide markers after a short term, submaximal, exercise in sickle cell trait carriers.
MedLine Citation:
PMID:  20571229     Owner:  NLM     Status:  MEDLINE    
The present study investigated the hemorheological and endothelial alterations in sickle cell trait (SCT) carriers in response to a submaximal exercise. Eleven SCT carriers and 11 subjects with normal hemoglobin performed submaximal exercise for 15 min. Blood was sampled at rest, at the end of exercise, and at 2 and 24 h of recovery. Hemorheological alterations observed in the SCT group were as follows: 1) lower RBC deformability at high shear stress at all time-points, with no relation to oxidative stress, 2) higher disaggregation threshold at all time-points, suggesting RBC hyper-aggregation, and 3) higher blood viscosity at the end of exercise and during recovery. Exercise had a specific influence on the levels of the soluble cell adhesion molecules P and L-selectin in the SCT carriers, with higher P-selectin levels at all time-points and a greater increase in L-selectin levels during recovery. SCT carriers had slightly decreased nitrite levels at 24h of recovery, which might be clinically insignificant. In conclusion, the hemorheological alterations in association with lower NO production found in the SCT carriers are probably not sufficient to explain the medical complications sometimes reported in SCT carriers after exercise.
Julien Tripette; Philippe Connes; Eric Beltan; Tawfik Chalabi; Laurent Marlin; Roger Chout; Oguz K Baskurt; Olivier Hue; Marie-Dominique Hardy-Dessources
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical hemorheology and microcirculation     Volume:  45     ISSN:  1875-8622     ISO Abbreviation:  Clin. Hemorheol. Microcirc.     Publication Date:  2010  
Date Detail:
Created Date:  2010-06-23     Completed Date:  2010-09-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9709206     Medline TA:  Clin Hemorheol Microcirc     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  39-52     Citation Subset:  IM    
Laboratoire ACTES (EA 3596), Département de Physiologie, Université des Antilles et de la Guyane, Pointe-à-Pitre, France.
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MeSH Terms
Blood Viscosity
Cell Adhesion Molecules / blood*
Erythrocyte Aggregation / physiology*
Erythrocyte Deformability / physiology*
Exercise Test
L-Selectin / blood
Leukocyte Count
Nitric Oxide / blood*
Nitrites / blood
Oxidative Stress*
P-Selectin / blood
Sickle Cell Trait / blood*
Reg. No./Substance:
0/Cell Adhesion Molecules; 0/Nitrites; 0/P-Selectin; 10102-43-9/Nitric Oxide; 126880-86-2/L-Selectin

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