Document Detail

Red blood cell-bound C3d in selected hospital patients.
MedLine Citation:
PMID:  6216638     Owner:  NLM     Status:  MEDLINE    
A radioactive anti-antiglobulin technique was used to measure C3d bound to the red blood cells of 227 hospitalized patients in 129 patients, with a wide variety of diseases, normal levels of RBC-bound C3d were found. Seventy-two patients had moderately elevated RBC-bound C3d; they generally did not have autoimmune hemolytic anemia but had diseases in which complement is thought to be activated. Patients with markedly elevated RBC-bound C3d (26 patients) usually had autoimmune hemolytic anemia with a positive antiglobulin test. Some patients with only moderately elevated levels of RBC-bound C3d had autoimmune hemolytic anemia and a negative antiglobulin test in individual patients the level of RBC-bound C3d correlated with both the severity of disease and the response to treatment. RBC-bound C3b was detected in two patients with a very high level of RBC-bound C3d. This study provides background data for assessing the significance of complement activation and fixation to RBC in health and disease.
J Freedman; M Ho; C Barefoot
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Transfusion     Volume:  22     ISSN:  0041-1132     ISO Abbreviation:  Transfusion     Publication Date:    1982 Nov-Dec
Date Detail:
Created Date:  1983-01-07     Completed Date:  1983-01-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0417360     Medline TA:  Transfusion     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  515-20     Citation Subset:  IM    
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MeSH Terms
Anemia, Hemolytic, Autoimmune / blood
Coombs' Test
Erythrocytes / metabolism*
Receptors, Complement / blood*
Receptors, Complement 3d
Reg. No./Substance:
0/Receptors, Complement; 0/Receptors, Complement 3d

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