| Red blood cell-bound C3d in selected hospital patients. | |
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MedLine Citation:
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PMID: 6216638 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A radioactive anti-antiglobulin technique was used to measure C3d bound to the red blood cells of 227 hospitalized patients in 129 patients, with a wide variety of diseases, normal levels of RBC-bound C3d were found. Seventy-two patients had moderately elevated RBC-bound C3d; they generally did not have autoimmune hemolytic anemia but had diseases in which complement is thought to be activated. Patients with markedly elevated RBC-bound C3d (26 patients) usually had autoimmune hemolytic anemia with a positive antiglobulin test. Some patients with only moderately elevated levels of RBC-bound C3d had autoimmune hemolytic anemia and a negative antiglobulin test in individual patients the level of RBC-bound C3d correlated with both the severity of disease and the response to treatment. RBC-bound C3b was detected in two patients with a very high level of RBC-bound C3d. This study provides background data for assessing the significance of complement activation and fixation to RBC in health and disease. |
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Authors:
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J Freedman; M Ho; C Barefoot |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Transfusion Volume: 22 ISSN: 0041-1132 ISO Abbreviation: Transfusion Publication Date: 1982 Nov-Dec |
Date Detail:
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Created Date: 1983-01-07 Completed Date: 1983-01-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0417360 Medline TA: Transfusion Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 515-20 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anemia, Hemolytic, Autoimmune
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blood Coombs' Test Erythrocytes / metabolism* Humans Receptors, Complement / blood* Receptors, Complement 3d |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Complement; 0/Receptors, Complement 3d |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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