Document Detail

Red blood cell-bound C3d in selected hospital patients.
MedLine Citation:
PMID:  6216638     Owner:  NLM     Status:  MEDLINE    
A radioactive anti-antiglobulin technique was used to measure C3d bound to the red blood cells of 227 hospitalized patients in 129 patients, with a wide variety of diseases, normal levels of RBC-bound C3d were found. Seventy-two patients had moderately elevated RBC-bound C3d; they generally did not have autoimmune hemolytic anemia but had diseases in which complement is thought to be activated. Patients with markedly elevated RBC-bound C3d (26 patients) usually had autoimmune hemolytic anemia with a positive antiglobulin test. Some patients with only moderately elevated levels of RBC-bound C3d had autoimmune hemolytic anemia and a negative antiglobulin test in individual patients the level of RBC-bound C3d correlated with both the severity of disease and the response to treatment. RBC-bound C3b was detected in two patients with a very high level of RBC-bound C3d. This study provides background data for assessing the significance of complement activation and fixation to RBC in health and disease.
J Freedman; M Ho; C Barefoot
Related Documents :
16573298 - Low cobalamin levels in african americans with and without sickle cell disease.
1251138 - Foamy histiocytosis of the spleen in patients with chronic thrombocytopenia.
20179008 - Acute kidney injury in sickle patients with painful crisis or acute chest syndrome and ...
2221608 - Spontaneous splenic rupture following infectious mononucleosis.
7127458 - Aspirin treatment of migraine attacks: clinical observations.
23173608 - Changed adipocytokine concentrations in colorectal tumor patients and morbidly obese pa...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Transfusion     Volume:  22     ISSN:  0041-1132     ISO Abbreviation:  Transfusion     Publication Date:    1982 Nov-Dec
Date Detail:
Created Date:  1983-01-07     Completed Date:  1983-01-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0417360     Medline TA:  Transfusion     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  515-20     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anemia, Hemolytic, Autoimmune / blood
Coombs' Test
Erythrocytes / metabolism*
Receptors, Complement / blood*
Receptors, Complement 3d
Reg. No./Substance:
0/Receptors, Complement; 0/Receptors, Complement 3d

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Red blood cell-bound C3d in normal subjects and in random hospital patients.
Next Document:  Renal lesions in MRL mice.