Document Detail

Red blood cell alloimmunization in sickle cell disease: pathophysiology, risk factors, and transfusion management.
MedLine Citation:
PMID:  22563085     Owner:  NLM     Status:  MEDLINE    
Red blood cell transfusions have reduced morbidity and mortality for patients with sickle cell disease. Transfusions can lead to erythrocyte alloimmunization, however, with serious complications for the patient including life-threatening delayed hemolytic transfusion reactions and difficulty in finding compatible units, which can cause transfusion delays. In this review, we discuss the risk factors associated with alloimmunization with emphasis on possible mechanisms that can trigger delayed hemolytic transfusion reactions in sickle cell disease, and we describe the challenges in transfusion management of these patients, including opportunities and emerging approaches for minimizing this life-threatening complication.
Karina Yazdanbakhsh; Russell E Ware; France Noizat-Pirenne
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2012-05-04
Journal Detail:
Title:  Blood     Volume:  120     ISSN:  1528-0020     ISO Abbreviation:  Blood     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-07-23     Completed Date:  2012-10-02     Revised Date:  2013-07-23    
Medline Journal Info:
Nlm Unique ID:  7603509     Medline TA:  Blood     Country:  United States    
Other Details:
Languages:  eng     Pagination:  528-37     Citation Subset:  AIM; IM    
Laboratory of Complement Biology, New York Blood Center, 310 East 67th St, NewYork, NY 10065, USA.
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MeSH Terms
Anemia, Sickle Cell / epidemiology,  immunology*,  physiopathology
Blood Group Incompatibility / immunology*
Blood Transfusion*
Erythrocytes / immunology*
Isoantigens / immunology*
Risk Factors
Grant Support
Reg. No./Substance:

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