Document Detail


Red blood cell T-activation and hemolysis in surgical intensive care patients with severe infections.
MedLine Citation:
PMID:  3814829     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The exposure of Thomsen-Friedenreich (T) antigens on RBCs, serum neuraminidase, and serum hemoglobin levels were investigated in 53 adult surgical intensive care unit (ICU) patients with septicemia. Unmasked T-antigens were assayed by a hemagglutination test using peanut agglutinin (PNA) (direct anti-T test), and by an indirect anti-T test employing rabbit anti-PNA globulin. RBC T-activation was demonstrated in 17/53 patients (32%); in 2/53 patients (4%) the direct anti-T test was positive, indicating strong T-exposure. No polyagglutination phenomena were observed. Serum neuraminidase was elevated in 12/17 (71%) patients with T-activation and in 7/36 (19%) patients without T-activation. Free serum hemoglobin was elevated in 12/17 (71%) patients with T-activation and in 5/36 (14%) patients without T-activation. Correlations between T-activation and serum neuraminidase and between T-activation and serum hemoglobin were significant (p less than 0.001). Potentially neuraminidase-releasing bacteria were demonstrated in 13/17 (76%) patients with RBC T-exposure. We conclude that neuraminidase-induced RBC T-activation and subsequent hemolysis may be involved in the pathomechanism of hemolytic anemia in patients with severe infections.
Authors:
G Lenz; U Goes; D Baron; U Sugg; W Heller
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Blut     Volume:  54     ISSN:  0006-5242     ISO Abbreviation:  Blut     Publication Date:  1987 Feb 
Date Detail:
Created Date:  1987-03-30     Completed Date:  1987-03-30     Revised Date:  2007-12-05    
Medline Journal Info:
Nlm Unique ID:  0173401     Medline TA:  Blut     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  89-96     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Antigens, Tumor-Associated, Carbohydrate*
Critical Care*
Disaccharides / immunology*
Erythrocytes / immunology*
Female
Hemoglobins / analysis
Hemolysis*
Humans
Infection / complications,  immunology*,  microbiology
Male
Middle Aged
Neuraminidase / blood,  pharmacology
Postoperative Complications* / immunology*
Chemical
Reg. No./Substance:
0/Antigens, Tumor-Associated, Carbohydrate; 0/Disaccharides; 0/Hemoglobins; 3554-90-3/Thomsen-Friedenreich antigen; EC 3.2.1.18/Neuraminidase

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