| Red blood cell T-activation and hemolysis in surgical intensive care patients with severe infections. | |
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MedLine Citation:
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PMID: 3814829 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The exposure of Thomsen-Friedenreich (T) antigens on RBCs, serum neuraminidase, and serum hemoglobin levels were investigated in 53 adult surgical intensive care unit (ICU) patients with septicemia. Unmasked T-antigens were assayed by a hemagglutination test using peanut agglutinin (PNA) (direct anti-T test), and by an indirect anti-T test employing rabbit anti-PNA globulin. RBC T-activation was demonstrated in 17/53 patients (32%); in 2/53 patients (4%) the direct anti-T test was positive, indicating strong T-exposure. No polyagglutination phenomena were observed. Serum neuraminidase was elevated in 12/17 (71%) patients with T-activation and in 7/36 (19%) patients without T-activation. Free serum hemoglobin was elevated in 12/17 (71%) patients with T-activation and in 5/36 (14%) patients without T-activation. Correlations between T-activation and serum neuraminidase and between T-activation and serum hemoglobin were significant (p less than 0.001). Potentially neuraminidase-releasing bacteria were demonstrated in 13/17 (76%) patients with RBC T-exposure. We conclude that neuraminidase-induced RBC T-activation and subsequent hemolysis may be involved in the pathomechanism of hemolytic anemia in patients with severe infections. |
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Authors:
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G Lenz; U Goes; D Baron; U Sugg; W Heller |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Blut Volume: 54 ISSN: 0006-5242 ISO Abbreviation: Blut Publication Date: 1987 Feb |
Date Detail:
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Created Date: 1987-03-30 Completed Date: 1987-03-30 Revised Date: 2007-12-05 |
Medline Journal Info:
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Nlm Unique ID: 0173401 Medline TA: Blut Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 89-96 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Antigens, Tumor-Associated, Carbohydrate* Critical Care* Disaccharides / immunology* Erythrocytes / immunology* Female Hemoglobins / analysis Hemolysis* Humans Infection / complications, immunology*, microbiology Male Middle Aged Neuraminidase / blood, pharmacology Postoperative Complications* / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Antigens, Tumor-Associated, Carbohydrate; 0/Disaccharides; 0/Hemoglobins; 3554-90-3/Thomsen-Friedenreich antigen; EC 3.2.1.18/Neuraminidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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