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Red Wine and Cardiovascular Health.
MedLine Citation:
PMID:  22955729     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
There is strong epidemiological evidence that light-to-moderate consumption of alcoholic drinks, but neither zero nor more than moderate intake, reduces mortality from all causes and also diminishes cardiovascular risk.(1) The lowest risk for coronary heart disease mortality is seen with 1-2 drinks (12.5-25 g alcohol) per day.Hypertension is a major risk factor for cardiovascular disease, and there is a clear inverse relationship between light-to-moderate alcohol intake and blood pressure. Thus, the reduced cardiovascular risk associated with moderate consumption of alcoholic drinks may be due, in part, to a reduction in blood pressure. The greatest blood pressure benefit seems to be obtained with one drink per day for women and with two drinks per day for men.(2)In most published studies, red wine has been used as the alcoholic test beverage. Red wine produces concentration-dependent vasodilator effects in subcutaneous small resistance arteries obtained from patients with essential hypertension.(3) In addition, red wine and dealcoholized red wine increase flow-mediated vasodilatation (FMD) of the brachial artery in healthy subjects.(4,5) Intake of red wine also counteracts endothelial dysfunction produced by high fat diet in human volunteers 6, and red wine increases FMD and decreases blood pressure in adult cigarette smokers.(7,8) [Extract].
Authors:
Huige Li; Ulrich Forstermann
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-6
Journal Detail:
Title:  Circulation research     Volume:  -     ISSN:  1524-4571     ISO Abbreviation:  Circ. Res.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0047103     Medline TA:  Circ Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Johannes Gutenberg University Medical Center, Mainz, Germany.
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