Document Detail

Red Blood Cell Distribution Width as an Effective Tool for Detecting Fatal Heart Failure in Super-elderly Patients.
MedLine Citation:
PMID:  22975534     Owner:  NLM     Status:  In-Data-Review    
Objective Red blood cell distribution width (RDW) is a numerical measure of erythrocyte size variation. It has been recently reported to be an independent prognostic marker of heart failure (HF). Previous studies on RDW were mostly designed for middle-aged and elderly patients (60-79 years old), therefore, there is no established limit for super-elderly patients (≥80 years old). The purpose of this study was to evaluate RDW as an effective tool to detect fatal HF in super-elderly patients. Methods The medical records and death certificates of 160 consecutive patients admitted to the Department of Cardiology in Juntendo Tokyo Koto Geriatric Medical Center and who died from June 2002 to October 2010 were reviewed. The causes of death were reviewed, and the factors, including RDW, that might have been related to the fatal HF were evaluated using multivariate logistic regression analysis. Results HF was the major cause of death [52 patients (32.5%), 29 females, age 84.0±7.5 years], followed by pneumonia (18.8%, 30/160), and acute myocardial infarction (16.3%, 26/160). The most common cause of HF was atrial fibrillation (36.6%, 19/52), followed by hypertensive heart disease (19.2%, 10/52) and valvular disorders (17.3%, 9/52). The multivariate logistic regression analysis found that a high RDW (≥16.5%) was an independent factor related to fatal HF (OR 2.36, 95% CI 1.10, 5.04, p=0.03). Conclusion HF was the major cause of death, and RDW ≥16.5 was significantly associated with fatal HF in super-elderly patients.
Yuji Nishizaki; Shinichiro Yamagami; Hikaru Suzuki; Yusuke Joki; Shuuhei Takahashi; Masahiro Sesoko; Haruyo Yamashita; Kenichi Kuremoto; Tomohiro Shinozaki; Hiroyuki Daida
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Publication Detail:
Type:  Journal Article     Date:  2012-09-01
Journal Detail:
Title:  Internal medicine (Tokyo, Japan)     Volume:  51     ISSN:  1349-7235     ISO Abbreviation:  Intern. Med.     Publication Date:  2012  
Date Detail:
Created Date:  2012-09-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9204241     Medline TA:  Intern Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  2271-6     Citation Subset:  IM    
Department of Cardiology, Juntendo University School of Medicine, Juntendo Tokyo Koto Geriatric Medical Center, Japan.
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