| Red American ginseng: ginsenoside constituents and antiproliferative activities of heat-processed Panax quinquefolius roots. | |
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MedLine Citation:
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PMID: 17538869 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Red Asian ginseng ( Panax ginseng C. A. Meyer, Araliaceae) is used in many Oriental countries. In this study, the saponin constituents and anticancer activities of steamed American ginseng ( Panax quinquefolius L.) roots were evaluated. The contents of 12 ginsenosides in the roots were determined using high performance liquid chromatography (HPLC). After the steaming treatment (100 - 120 degrees C for 1 h and 120 degrees C for 0.5 - 4 h), the quantity of 7 ginsenosides decreased and that of 5 others increased. The content of ginsenoside Rg3, a previously recognized anticancer compound, increased significantly when the root was steamed at 120 degrees C for 0.5 - 3 h. The antiproliferative effects of unsteamed and steamed (120 degrees C for 1 h and 2 h) American ginseng root extracts were assayed by the modified trichrome stain (MTS) method using three cancer cell lines (SW-480, HT-29, NSCLC). Heat-processing increased the antiproliferative effect of American ginseng significantly, and the activity of the extract from roots steamed for 2 h was greater than that of roots steamed for 1 h. Chemical constituents and antiproliferative activities of white and red Asian ginseng have also been evaluated. Five representative ginsenosides, Rb1, Rd, Re, Rg2 and Rg3, were studied. Ginsenoside Rg3 had the most potent effect. The antiproliferative activities of red American ginseng are augmented when ginsenoside Rg3 is increased. |
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Authors:
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Chong-Zhi Wang; Han H Aung; Ming Ni; Ji-An Wu; Robin Tong; Sheila Wicks; Tong-Chuan He; Chun-Su Yuan |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2007-05-31 |
Journal Detail:
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Title: Planta medica Volume: 73 ISSN: 0032-0943 ISO Abbreviation: Planta Med. Publication Date: 2007 Jun |
Date Detail:
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Created Date: 2007-07-10 Completed Date: 2007-10-25 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 0066751 Medline TA: Planta Med Country: Germany |
Other Details:
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Languages: eng Pagination: 669-74 Citation Subset: IM |
Affiliation:
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Tang Center for Herbal Medicine Research, University of Chicago, Chicago, Illinois 60637, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Agents, Phytogenic
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administration & dosage,
chemistry,
pharmacology*,
therapeutic use Cell Line, Tumor / drug effects Cell Proliferation / drug effects Dose-Response Relationship, Drug Ginsenosides / administration & dosage, chemistry, pharmacology*, therapeutic use Hot Temperature Humans Panax* Phytotherapy* Plant Extracts / administration & dosage, chemistry, pharmacology*, therapeutic use Plant Roots |
| Grant Support | |
ID/Acronym/Agency:
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1R01 CA106569-01/CA/NCI NIH HHS; AT002176/AT/NCCAM NIH HHS; AT002445/AT/NCCAM NIH HHS; R21 AT002176-02/AT/NCCAM NIH HHS; R21 AT002445-02/AT/NCCAM NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents, Phytogenic; 0/Ginsenosides; 0/Plant Extracts; 14197-60-5/ginsenoside Rg3 |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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