| Recurrent skin eruption in patient with chronic lymphocytic leukemia and lymphocytic infiltrates of the dermis resembling Sweet's syndrome. | |
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MedLine Citation:
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PMID: 22095180 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Sweet's syndrome (acute febrile dermatosis) is characterized by fever, peripheral neutrophil leukocytosis, acute onset of tender erythematous skin lesions (papules, nodules or plaques), and histological findings of a dense infiltrate consisting predominantly of mature neutrophils. Malignancy-associated Sweet's syndrome constitutes approximately 21% of patients, the majority of whom suffer from hematologic disorder. We report the case of patient with chronic lymphocytic leukemia with recurrent eruptions of tender, pseudovesiculated nodules and plaques with good response to corticosteroid therapy, resembling Sweet's syndrome. However, histological examination revealed lymphocytic infiltrate in the dermis, which made impossible to establish diagnosis of acute febrile dermatosis according to diagnostic criteria. Association of the skin eruptions with leukemia was implied by improvement of skin lesions after chemotherapy. We present review of the literature reporting cases with atypical histopathological presentations which preceded classical histological appearances, that were mainly associated with hematological malignancies and discuss them in the context of our patient. |
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Authors:
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B Wawrzycki; G Chodorowska; A Pietrzak; D W Krasowska; Sz Wąsik; E Dybiec; T Lotti; J Hercegova |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Giornale italiano di dermatologia e venereologia : organo ufficiale, Società italiana di dermatologia e sifilografia Volume: 146 ISSN: 0026-4741 ISO Abbreviation: G Ital Dermatol Venereol Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-11-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8102852 Medline TA: G Ital Dermatol Venereol Country: Italy |
Other Details:
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Languages: eng Pagination: 487-2 Citation Subset: IM |
Affiliation:
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Department of Dermatology, Venereology and Pediatric Dermatology, Medical University of Lublin, Lublin, Poland - bartekwawrzycki@o2.pl. |
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