Document Detail

Recurrent short-lasting headache associated with paroxysmal hypertension: a clonidine-responsive syndrome.
MedLine Citation:
PMID:  11037747     Owner:  NLM     Status:  MEDLINE    
The clinical syndrome of hypertension, headache, palpitation, diaphoresis, flushing, and emotional lability is classically associated with pheochromocytoma. Two patients are presented with this constellation of symptoms in whom investigations for pheochromocytoma were unrevealing. Headache was the presenting and most prominent complaint, with daily episodes of short-lasting, intermittent, and paroxysmal attacks. Each paroxysm of headache was associated with a dramatic increase in systolic and diastolic blood pressure. After failure to control the labile fluctuations in blood pressure and headache with several classes of anti-hypertensive medications used in combination, a prompt and persistent response occurred after the administration of clonidine. The pathophysiology of this syndrome and the mechanism of clonidine action are reviewed in the context of a possible failure of the baroreceptor reflex.
D W Dodick
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Cephalalgia : an international journal of headache     Volume:  20     ISSN:  0333-1024     ISO Abbreviation:  Cephalalgia     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2001-01-22     Completed Date:  2001-02-01     Revised Date:  2008-02-11    
Medline Journal Info:
Nlm Unique ID:  8200710     Medline TA:  Cephalalgia     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  509-14     Citation Subset:  IM    
Department of Neurology, Mayo Clinic and Mayo Foundation, Rochester, MN, USA.
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MeSH Terms
Acute Disease
Antihypertensive Agents / therapeutic use*
Clonidine / therapeutic use*
Headache / drug therapy*,  etiology*
Hypertension / complications*,  drug therapy*
Middle Aged
Reg. No./Substance:
0/Antihypertensive Agents; 4205-90-7/Clonidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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