Document Detail


Recurrent severe hyperandrogenism during pregnancy: a case report.
MedLine Citation:
PMID:  15790717     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This report describes the case of a 28 year old woman with virilisation occurring in two successive pregnancies. Recurrent maternal virilisation is rare (seven previous reports) and this case is unique in its severity. Differential diagnoses include ovarian disease and fetal aromatase deficiency. New techniques to exclude a fetal cause were used in this case. This patient presented during the third trimester of her first pregnancy with rapid onset of hirsuitism, increased musculature, and deepening voice. A blood hormone profile revealed significant hyperandrogenism (testosterone, 72.4 nmol/litre; normal range, 0.5-3.0). She delivered a normal boy and maternal androgen concentrations returned rapidly to normal (testosterone, 0.8 nmol/litre). She presented two years later, during her second pregnancy, with similar symptoms and biochemistry (testosterone, 47.5 nmol/litre). Again, she delivered a healthy normal boy and androgens returned immediately to normal (serum testosterone, 2.0 nmol/litre). Ultrasonography revealed no evidence of ovarian (or adrenal) masses in either pregnancy. Umbilical cord venous blood sampling and placental assays revealed no evidence of fetal aromatase deficiency. Recurrent hyperandrogenism during pregnancy is rare. Ovarian luteoma rarely recurs and hyperreactio luteinalis does not lead to such pronounced androgen concentrations. Therefore, this patient has a unique ovarian condition that could be harmful to offspring and mother.
Authors:
H B Holt; S Medbak; D Kirk; R Guirgis; I Hughes; M H Cummings; D R Meeking
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of clinical pathology     Volume:  58     ISSN:  0021-9746     ISO Abbreviation:  J. Clin. Pathol.     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-03-25     Completed Date:  2005-05-10     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0376601     Medline TA:  J Clin Pathol     Country:  England    
Other Details:
Languages:  eng     Pagination:  439-42     Citation Subset:  AIM; IM    
Affiliation:
Academic Department of Diabetes and Endocrinology, Portsmouth Hospitals NHS Trust, Portsmouth PO6 3LY, UK. hbholt@doctors.net.uk
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MeSH Terms
Descriptor/Qualifier:
Adult
Androgens / blood
Aromatase / analysis
Female
Hirsutism / diagnosis,  metabolism
Humans
Hyperandrogenism / diagnosis*,  metabolism
Placenta / enzymology
Pregnancy
Pregnancy Complications / diagnosis*,  metabolism
Virilism / diagnosis,  metabolism
Chemical
Reg. No./Substance:
0/Androgens; EC 1.14.14.1/Aromatase
Comments/Corrections

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