Document Detail

Recurrent severe bleeding from gastrointestinal angiodysplasia in a patient with von Willebrand's disease, controlled with recombinant factor VIIa.
MedLine Citation:
PMID:  11414636     Owner:  NLM     Status:  MEDLINE    
A patient with von Willebrand's disease had recurrent gastrointestinal bleeding from angiodysplasia, with inadequate response to von Willebrand factor substitution, medical and endoscopic treatment, and resection of affected bowel. Frequent blood transfusions were required. She started home treatment with recombinant activated factor VII (rFVIIa) at the onset of bleeding, in addition to her standard therapy. From then on, bleeds could be controlled rapidly and no more blood transfusions were needed. We conclude that rFVIIa is effective in this case of angiodysplasia and might be a therapeutic option in similar patients.
K Meijer; F T Peters; J van der Meer
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis     Volume:  12     ISSN:  0957-5235     ISO Abbreviation:  Blood Coagul. Fibrinolysis     Publication Date:  2001 Apr 
Date Detail:
Created Date:  2001-06-20     Completed Date:  2001-12-04     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9102551     Medline TA:  Blood Coagul Fibrinolysis     Country:  England    
Other Details:
Languages:  eng     Pagination:  211-3     Citation Subset:  IM    
Division of Haemostasis, Thrombosis and Rheology, University Hospital Groningen, The Netherlands.
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MeSH Terms
Angiodysplasia / complications*
Blood Transfusion
Combined Modality Therapy
Deamino Arginine Vasopressin / therapeutic use
Estrogens / therapeutic use
Factor VIII / therapeutic use
Factor VIIa / therapeutic use*
Gastrointestinal Hemorrhage / etiology*,  surgery,  therapy
Iron / therapeutic use
Jejunal Diseases / complications*,  surgery
Melena / etiology
Middle Aged
Omeprazole / therapeutic use
Recombinant Proteins / therapeutic use
Tranexamic Acid / therapeutic use
Treatment Outcome
von Willebrand Diseases / complications*,  drug therapy
von Willebrand Factor / therapeutic use
Reg. No./Substance:
0/Estrogens; 0/Recombinant Proteins; 0/von Willebrand Factor; 1197-18-8/Tranexamic Acid; 16679-58-6/Deamino Arginine Vasopressin; 73590-58-6/Omeprazole; 7439-89-6/Iron; 9001-27-8/Factor VIII; EC VIIa

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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