| Recurrent respiratory papillomatosis: a complex defect in immune responsiveness to human papillomavirus-6 and -11. | |
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MedLine Citation:
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PMID: 20553528 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recurrent respiratory papillomatosis (RRP) is a rare disease of the larynx caused by infection with human papillomaviruses (HPV) -6 or -11, associated with significant morbidity and on occasion mortality. Here we summarize our current understanding of the permissive adaptive and innate responses made by patients with RRP that support chronic HPV infection and prevent immune clearance of these viruses. Furthermore, we provide new evidence of T(H)2-like polarization in papillomas and blood of patients with RRP, restricted CD4 and CD8 Vbeta repertoires, the effect of HPV-11 early protein E6 on T-cell alloreactivity, enriched Langerhans cell presence in papillomas, and evidence that natural killer cells are dysfunctional in RRP. We review the immunogenetic mechanisms that regulate the dysfunctional responses made by patients with RRP in response to HPV infection of the upper airway. In addition, we are identifying T-cell epitopes on HPV-11 early proteins, in the context of human leukocyte antigen (HLA) class II alleles enriched in RRP that should help generate a therapeutic vaccine. Taken together, RRP is a complex, multigene disease manifesting as a tissue and HPV-specific, immune deficiency that prevents effective clearance and/or control of HPV-6 and -11 infection. |
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Authors:
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Vincent R Bonagura; Lynda J Hatam; David W Rosenthal; James A de Voti; Fung Lam; Bettie M Steinberg; Allan L Abramson |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica Volume: 118 ISSN: 1600-0463 ISO Abbreviation: APMIS Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-17 Completed Date: 2010-07-01 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 8803400 Medline TA: APMIS Country: Denmark |
Other Details:
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Languages: eng Pagination: 455-70 Citation Subset: IM |
Affiliation:
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Feinstein Institute for Medical Research, North Shore-Long Island Jewish Health System, Manhasset, NY, USA. bonagura@lij.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cytokines
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biosynthesis Human papillomavirus 11 / immunology* Human papillomavirus 6 / immunology* Humans Laryngeal Neoplasms / epidemiology, immunology*, therapy Neoplasm Recurrence, Local Papilloma Papillomavirus Infections / epidemiology, immunology*, therapy Papillomavirus Vaccines / therapeutic use T-Lymphocytes, Regulatory / immunology Th1 Cells / immunology Th2 Cells / immunology |
| Grant Support | |
ID/Acronym/Agency:
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R01 DE017227-04/DE/NIDCR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/Papillomavirus Vaccines |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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