Document Detail

Recurrent prognostic factors and expression of GLUT-1, PI3K and p-Akt in adenoid cystic carcinomas of the head and neck: Clinicopathological features and biomarkers of adenoid cystic carcinoma.
MedLine Citation:
PMID:  23226799     Owner:  NLM     Status:  Publisher    
The purpose of this study was to explore the factors associated with the recurrence of adenoid cystic carcinomas (ACCs). We examined the recurrence values of clinicopathological variables and GLUT-1, p-Akt and PI3K expression in 42 patients with ACC. Of the 42 patients, 17 developed recurrence following initial surgery. The positive rates of GLUT-1, PI3K and p-Akt protein expression in ACC were 38.1, 38.1 and 50.0%, respectively. The expression of GLUT-1, p-Akt or PI3K protein in ACC was higher than that in inflammatory lesions or benign tumors. Our study demonstrated that T stage, a positive resection margin, perineural invasion, surgery without postoperative radiotherapy and the expression of GLUT-1, PI3K and p-Akt were factors predictive of recurrence by univariate analyses. In multivariate analyses, perineural invasion, a positive resection margin and p-Akt were significant predictors of recurrence. Initial surgery is very significant in the recurrence of ACC. Overexpression of GLUT-1, PI3K and p-Akt may also play a role in its development and recurrence.
Jin Fang; Yang-Yang Bao; Shui-Hong Zhou; Xing-Mei Luo; Hong-Tian Yao; Jian-Feng He; Qin-Ying Wang
Related Documents :
23027639 - Impact of high dose chemoimmunotherapy after surgery on the overall and disease-free su...
22054889 - A decade of advances in treatment of early-stage lung cancer.
24002769 - Trends in the treatment of resectable pancreatic adenocarcinoma.
19440819 - Mediastinal lymph node carcinoma of an unknown primary site: clinicopathological examin...
6268879 - Small cell carcinoma presenting as an extrapulmonary neoplasm: sites of origin and resp...
20738899 - Is there a role for surgery in stage iiia-n2 non-small cell lung cancer?
2465939 - Bleomycin, vincristine, mitomycin c, and cis-platinum in gynecologic squamous cell carc...
1688729 - Adult wilms' tumor. cisplatin and etoposide for relapse after adjuvant chemotherapy.
18683299 - The miles-2g phase 2 study of single-agent gemcitabine with prolonged constant infusion...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-05
Journal Detail:
Title:  Oncology letters     Volume:  4     ISSN:  1792-1074     ISO Abbreviation:  Oncol Lett     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101531236     Medline TA:  Oncol Lett     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1234-1240     Citation Subset:  -    
Department of Otolaryngology, The Second Hospital of Jiaxing City, Jiaxing 314000; ; Departments of Otolaryngology.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Antitumor effect of the selective COX-2 inhibitor celecoxib on endometrial adenocarcinoma in vitro a...
Next Document:  Clear cell myoepithelial carcinoma in the base of the tongue: Case report and review of the literatu...