Document Detail

Recurrent prognostic factors and expression of GLUT-1, PI3K and p-Akt in adenoid cystic carcinomas of the head and neck: Clinicopathological features and biomarkers of adenoid cystic carcinoma.
MedLine Citation:
PMID:  23226799     Owner:  NLM     Status:  Publisher    
The purpose of this study was to explore the factors associated with the recurrence of adenoid cystic carcinomas (ACCs). We examined the recurrence values of clinicopathological variables and GLUT-1, p-Akt and PI3K expression in 42 patients with ACC. Of the 42 patients, 17 developed recurrence following initial surgery. The positive rates of GLUT-1, PI3K and p-Akt protein expression in ACC were 38.1, 38.1 and 50.0%, respectively. The expression of GLUT-1, p-Akt or PI3K protein in ACC was higher than that in inflammatory lesions or benign tumors. Our study demonstrated that T stage, a positive resection margin, perineural invasion, surgery without postoperative radiotherapy and the expression of GLUT-1, PI3K and p-Akt were factors predictive of recurrence by univariate analyses. In multivariate analyses, perineural invasion, a positive resection margin and p-Akt were significant predictors of recurrence. Initial surgery is very significant in the recurrence of ACC. Overexpression of GLUT-1, PI3K and p-Akt may also play a role in its development and recurrence.
Jin Fang; Yang-Yang Bao; Shui-Hong Zhou; Xing-Mei Luo; Hong-Tian Yao; Jian-Feng He; Qin-Ying Wang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-05
Journal Detail:
Title:  Oncology letters     Volume:  4     ISSN:  1792-1074     ISO Abbreviation:  Oncol Lett     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101531236     Medline TA:  Oncol Lett     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1234-1240     Citation Subset:  -    
Department of Otolaryngology, The Second Hospital of Jiaxing City, Jiaxing 314000; ; Departments of Otolaryngology.
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