| Recurrent prognostic factors and expression of GLUT-1, PI3K and p-Akt in adenoid cystic carcinomas of the head and neck: Clinicopathological features and biomarkers of adenoid cystic carcinoma. | |
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MedLine Citation:
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PMID: 23226799 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The purpose of this study was to explore the factors associated with the recurrence of adenoid cystic carcinomas (ACCs). We examined the recurrence values of clinicopathological variables and GLUT-1, p-Akt and PI3K expression in 42 patients with ACC. Of the 42 patients, 17 developed recurrence following initial surgery. The positive rates of GLUT-1, PI3K and p-Akt protein expression in ACC were 38.1, 38.1 and 50.0%, respectively. The expression of GLUT-1, p-Akt or PI3K protein in ACC was higher than that in inflammatory lesions or benign tumors. Our study demonstrated that T stage, a positive resection margin, perineural invasion, surgery without postoperative radiotherapy and the expression of GLUT-1, PI3K and p-Akt were factors predictive of recurrence by univariate analyses. In multivariate analyses, perineural invasion, a positive resection margin and p-Akt were significant predictors of recurrence. Initial surgery is very significant in the recurrence of ACC. Overexpression of GLUT-1, PI3K and p-Akt may also play a role in its development and recurrence. |
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Authors:
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Jin Fang; Yang-Yang Bao; Shui-Hong Zhou; Xing-Mei Luo; Hong-Tian Yao; Jian-Feng He; Qin-Ying Wang |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-9-05 |
Journal Detail:
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Title: Oncology letters Volume: 4 ISSN: 1792-1074 ISO Abbreviation: Oncol Lett Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101531236 Medline TA: Oncol Lett Country: - |
Other Details:
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Languages: ENG Pagination: 1234-1240 Citation Subset: - |
Affiliation:
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Department of Otolaryngology, The Second Hospital of Jiaxing City, Jiaxing 314000; ; Departments of Otolaryngology. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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