Document Detail

Recurrent pregnancy loss and thrombophilia.
MedLine Citation:
PMID:  17605406     Owner:  NLM     Status:  MEDLINE    
In the last decades we found many data concerning the association between a hypercoagulable state and its causes and adverse pregnancy outcome, in particular recurrent pregnancy loss (RPL). Although first studies were focused only on the association between thrombophilia and RPL, subsequent studies underlined also a potential role of antithrombotic treatment to prevent vascular complication such as venous thromboembolism (VTE) during pregnancy. Now, emerging data seem to be available also on the role of active thromboprophylaxis with heparin and pregnancy outcome. This review will be focused on the recent knowledge between thrombophilia, hypercoagulable state, RPL, VTE and future perspectives.
Pierpaolo Di Micco; Maristella D'uva; Ida Strina; Giuseppe De Placido; Rosanna Di Fiore; Sandro Quaranta; Giuseppe Castaldo
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinical laboratory     Volume:  53     ISSN:  1433-6510     ISO Abbreviation:  Clin. Lab.     Publication Date:  2007  
Date Detail:
Created Date:  2007-07-03     Completed Date:  2008-01-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9705611     Medline TA:  Clin Lab     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  309-14     Citation Subset:  IM    
Internal Medicine Division, Buonconsiglio Fatebenefratelli Hospital of Naples, Naples, Italy.
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MeSH Terms
Abortion, Habitual / etiology*,  genetics
Antiphospholipid Syndrome / diagnosis
Heparin, Low-Molecular-Weight / therapeutic use*
Hyperhomocysteinemia / complications,  genetics
Methylenetetrahydrofolate Reductase (NADPH2) / genetics
Pregnancy Outcome
Thrombophilia / complications*,  drug therapy*,  genetics
Venous Thromboembolism / diagnosis,  drug therapy*
Reg. No./Substance:
0/Heparin, Low-Molecular-Weight; EC Reductase (NADPH2)

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