Document Detail

Recurrent pregnancy loss and antiphospholipid syndrome: an overlooked association.
MedLine Citation:
PMID:  21416793     Owner:  NLM     Status:  In-Process    
Antiphospholipid Syndrome (APS), a thrombophilic condition, is being increasingly recognised as an important cause of recurrent pregnancy loss, preeclampsia and possible infertility. It could occur as a primary condition or it may be secondary to connective tissue diseases, infections or malignancies. Though recurrent pregnancy loss is a common feature ofAPS, there are other presentations attributable to thrombosis. The mechanism of thrombosis is still not completely understood but there are various suggested mechanisms. Presence of anti-cardiolipin antibodies (aCL) and lupus anticoagulant (LAC) are diagnostic. Management is variously with heparin, aspirin and warfarin, although other treatment modalities are being deployed. A high index of suspicion is needed for this otherwise treatable condition. Management is ideally best done by an obstetrician and a rheumatologist.
O O Adelowo; O O Adetoro
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  African journal of medicine and medical sciences     Volume:  39     ISSN:  0309-3913     ISO Abbreviation:  Afr J Med Med Sci     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2011-03-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7801013     Medline TA:  Afr J Med Med Sci     Country:  Nigeria    
Other Details:
Languages:  eng     Pagination:  227-31     Citation Subset:  IM    
Rheumatology Unit, Department of Medicine, Olabisi Onabanjo University Teaching Hospital, Sagamu, Nigeria.
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