| Recurrent polytopic chromaffin paragangliomas in a 9-year-old boy resulting from a novel germline mutation in the von Hippel-Lindau gene. | |
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MedLine Citation:
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PMID: 11990703 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pheochromocytomas are frequently associated with inherited cancer syndromes such as von Hippel-Lindau disease (VHL). Retinal angioma and hemangioblastomas of the central nervous system are hallmarks of VHL, but its clinical variety is remarkably broad. Pheochromocytomas as the sole or first manifestation of VHL are rare but have been observed. In this case report, the authors describe an unusual case of initial collapse, seizures, and hypertensive crisis in a child who later was found to have multiple extraadrenal pheochromocytomas. Molecular diagnostics revealed a novel point mutation in the VHL gene (VHL nt. 406 T-->G). Only 7 months after the first lesions had been removed, a new paraganglioma developed in the contralateral periadrenal region. When encountering pheochromocytomas in children, the clinician should be aware that an associated tumor syndrome might be present, and appropriate molecular screening should be initiated. Molecular genetics aid in the clinical decision-making and clinical management of individual patients with pheochromocytoma. |
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Authors:
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Peter Reichardt; Thomas W Apel; Manfred Domula; Ralf-Bodo Tröbs; Ingrid Krause; Uta Bierbach; Hartmut P H Neumann; Wieland Kiess |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of pediatric hematology/oncology Volume: 24 ISSN: 1077-4114 ISO Abbreviation: J. Pediatr. Hematol. Oncol. Publication Date: 2002 Feb |
Date Detail:
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Created Date: 2002-05-06 Completed Date: 2002-06-04 Revised Date: 2011-10-06 |
Medline Journal Info:
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Nlm Unique ID: 9505928 Medline TA: J Pediatr Hematol Oncol Country: United States |
Other Details:
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Languages: eng Pagination: 145-8 Citation Subset: IM |
Affiliation:
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Intensive Care Unit, Children's Hospital of the University of Leipzig, Germany. reichp@medizin.unileipzig.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abdominal Neoplasms
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genetics* Amino Acid Substitution* Child Codon / genetics Diagnosis, Differential Humans Hypertension / etiology Ligases / genetics* Magnetic Resonance Imaging Male Mutation, Missense* Neuroblastoma / diagnosis Paraganglioma, Extra-Adrenal / genetics* Point Mutation* Seizures / etiology Thoracic Neoplasms / genetics* Tumor Suppressor Proteins* Ubiquitin-Protein Ligases* Von Hippel-Lindau Tumor Suppressor Protein von Hippel-Lindau Disease / diagnosis, genetics* |
| Chemical | |
Reg. No./Substance:
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0/Codon; 0/Tumor Suppressor Proteins; EC 6.-/Ligases; EC 6.3.2.19/Ubiquitin-Protein Ligases; EC 6.3.2.19/VHL protein, human; EC 6.3.2.19/Von Hippel-Lindau Tumor Suppressor Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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