| Recurrent partial hydatidiform mole, with a first twin pregnancy, after treatment with clomiphene citrate. | |
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MedLine Citation:
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PMID: 19499414 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We present a patient, treated for 3 months with clomiphen citrate after 5 years of infertility. This treatment resulted in a twin pregnancy, one degenerated into a partial hydatidiform mole and the other into a very early embryo death. The karyotype was a mosaic one: 63% of metaphases showed triploidy - 69 XXX and 37% diploidy - 46 XX. Despite all medical advice, she returned 8 months later with a new pregnancy, which proved to be a new partial hydatidiform mole, this time a single one. Karyotype was, also, a triploidy - 69 XXX. The genetic map of both genitors was performed, showing no aberrations. Unfortunately, the patient came back, once again, 5 months later, with a new positive pregnancy test. Ultrasonography revealed a new very early embryo death, the histopathological analysis establishing to be a single 'pure' stop in evolution of the pregnancy. As all the three pregnancies obtained after treatment with clomiphene were abnormal, two being partial hydatidiform moles and one being a premature miscarriage, without any genetic aberrations of the genitors, it seems very possible that clomiphene, apart from improving fertility, also increases the risk of abnormal ovum appearance. |
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Authors:
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Andrei Adrian Tica; Oana Sorina Tica; Claudia Valentina Georgescu; Francisc Mixich; Vlad Justin Tica; Sabina Berceanu; Elena Ebanca; Anca Patrascu; Cristina Simionescu |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology Volume: 25 ISSN: 1473-0766 ISO Abbreviation: Gynecol. Endocrinol. Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-11-11 Completed Date: 2010-01-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8807913 Medline TA: Gynecol Endocrinol Country: England |
Other Details:
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Languages: eng Pagination: 514-9 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, University of Medicine and Pharmacy Craiova, Craiova, Dolj, Romania. ticaandrei2002@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abortion, Spontaneous
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chemically induced Adult Clomiphene / adverse effects*, therapeutic use Embryo Loss / chemically induced Female Fertility Agents, Female / adverse effects*, therapeutic use Humans Hydatidiform Mole / chemically induced*, complications, pathology Infertility, Female / drug therapy Karyotyping Luteoma / ultrasonography Ovarian Neoplasms / ultrasonography Pregnancy Pregnancy, Multiple* Recurrence Twins* Ultrasonography, Prenatal Uterine Neoplasms / chemically induced*, complications, pathology |
| Chemical | |
Reg. No./Substance:
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0/Fertility Agents, Female; 911-45-5/Clomiphene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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