| Recurrent pancreatitis in mitochondrial cytopathy. | |
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MedLine Citation:
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PMID: 17022070 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Diabetes mellitus and exocrine insufficiency are the commonest pancreatic manifestations of mitochondrial diseases. In contrast, pancreatitis has rarely been described in mitochondrial syndromes. We report on a patient with Kearns-Sayre syndrome and recurrent episodes of acute pancreatitis for which no explanation could be found other than the associated mitochondrial dysfunction. Interestingly, pharmacological disruption of mitochondrial metabolism in various models as well as in patients can cause pancreatitis, further supporting this association. A diagnosis of pancreatitis should be considered in any patients with mitochondrial disease and recurrent abdominal pain. |
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Authors:
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François-Guillaume Debray; Eric Drouin; Denise Herzog; Anne Lortie; Marie Lambert; Laurent Garel; Grant A Mitchell; Jacques L Michaud |
Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: American journal of medical genetics. Part A Volume: 140 ISSN: 1552-4825 ISO Abbreviation: Am. J. Med. Genet. A Publication Date: 2006 Nov |
Date Detail:
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Created Date: 2006-11-01 Completed Date: 2007-01-12 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 101235741 Medline TA: Am J Med Genet A Country: United States |
Other Details:
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Languages: eng Pagination: 2330-5 Citation Subset: IM |
Affiliation:
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Division of Medical Genetics, Hôpital Sainte-Justine, Montreal, Québec, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adolescent DNA Mutational Analysis DNA, Mitochondrial / genetics Humans Kearns-Sayre Syndrome / complications*, genetics Male Pancreatic Pseudocyst / complications, radiography Pancreatitis / complications*, radiography Recurrence Sequence Deletion Tomography, X-Ray Computed |
| Chemical | |
Reg. No./Substance:
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0/DNA, Mitochondrial |
| Comments/Corrections | |
Comment In:
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Am J Med Genet A. 2007 Mar 15;143(6):632-3
[PMID:
17318846
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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