Document Detail

Recurrent pancreatitis in mitochondrial cytopathy.
MedLine Citation:
PMID:  17022070     Owner:  NLM     Status:  MEDLINE    
Diabetes mellitus and exocrine insufficiency are the commonest pancreatic manifestations of mitochondrial diseases. In contrast, pancreatitis has rarely been described in mitochondrial syndromes. We report on a patient with Kearns-Sayre syndrome and recurrent episodes of acute pancreatitis for which no explanation could be found other than the associated mitochondrial dysfunction. Interestingly, pharmacological disruption of mitochondrial metabolism in various models as well as in patients can cause pancreatitis, further supporting this association. A diagnosis of pancreatitis should be considered in any patients with mitochondrial disease and recurrent abdominal pain.
François-Guillaume Debray; Eric Drouin; Denise Herzog; Anne Lortie; Marie Lambert; Laurent Garel; Grant A Mitchell; Jacques L Michaud
Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  American journal of medical genetics. Part A     Volume:  140     ISSN:  1552-4825     ISO Abbreviation:  Am. J. Med. Genet. A     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-11-01     Completed Date:  2007-01-12     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  101235741     Medline TA:  Am J Med Genet A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2330-5     Citation Subset:  IM    
Division of Medical Genetics, Hôpital Sainte-Justine, Montreal, Québec, Canada.
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MeSH Terms
Acute Disease
DNA Mutational Analysis
DNA, Mitochondrial / genetics
Kearns-Sayre Syndrome / complications*,  genetics
Pancreatic Pseudocyst / complications,  radiography
Pancreatitis / complications*,  radiography
Sequence Deletion
Tomography, X-Ray Computed
Reg. No./Substance:
0/DNA, Mitochondrial
Comment In:
Am J Med Genet A. 2007 Mar 15;143(6):632-3   [PMID:  17318846 ]

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